Document Detail

Different effect of the pure Na+ channel-blocker pilsicainide on the ST-segment response in the right precordial leads in patients with normal left ventricular function.
MedLine Citation:
PMID:  17186979     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The response of the ST-segment in the right precordial leads to Na+ channel blockers in patients without structural heart disease and a typical Brugada-type ECG has not been fully elucidated. METHODS AND RESULTS: A pilsicainide challenge test was performed in 161 patients and according to recently established ECG criteria and an organized computer algorithm, the ST morphology was classified and the maximum increase in the J wave amplitude (maxDeltaJ) from the standard and high right precordial leads V1-3 was examined. Before the test, subjects exhibiting type 1 ECG in the standard leads were excluded. After administering pilsicainide, type 1 ECGs in the standard leads were observed in 31 cases and a maxDeltaJ of >or=200 microV was observed in 29 cases (23 type 1, 2 type 2/3 and 4 normal ECGs). In the additional higher right precordial leads, type 1 ECGs were observed in 55 cases and a maxDeltaJ of >or=200 microV was observed in 45 cases (42 type 1 and 3 type 2/3 ECGs). CONCLUSIONS: A maxDeltaJ>or=200 microV induced by pilsicainide, including that measured in the high right precordial leads, was associated with a change mainly to a type 1 ECG.
Takeshi Ueyama; Akihiko Shimizu; Toshihiko Yamagata; Masahiro Esato; Masato Ohmura; Yasuhiro Yoshiga; Masashi Kanemoto; Ryousuke Kametani; Akira Sawa; Shinsuke Suzuki; Naoki Sugi; Masunori Matsuzaki
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  71     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  57-62     Citation Subset:  IM    
Division of Cardiovascular Medicine, Department of Medical Bioregulation, Yamaguchi University Graduate School of Medicine, Hofu, Japan.
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MeSH Terms
Brugada Syndrome / physiopathology
Heart Diseases / pathology
Lidocaine / analogs & derivatives*,  pharmacology
Middle Aged
Prospective Studies
Sodium Channel Blockers / pharmacology*
Ventricular Function, Left / drug effects*,  physiology
Reg. No./Substance:
0/Sodium Channel Blockers; 137-58-6/Lidocaine; 88069-49-2/pilsicainide

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