| Different effect of ouabain on endothelin-1-induced extracellular signal-regulated kinase stimulation in rat heart and tail artery. | |
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MedLine Citation:
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PMID: 12658056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endogenous ouabain may play a role in the control of cardiovascular system function. In this study, we investigated the effects of a long-term ouabain treatment on basal and endothelin-1 (ET-1)-induced phosphorylation of cardiac and vascular extracellular signal-regulated kinases 1 and 2 (ERK-1 and ERK-2), which are involved in several cardiac and vascular physiologic and pathologic conditions. Our results show that the hearts from ouabain-treated rats have a higher basal level of ERK-1 and ERK-2 phosphorylation compared with untreated rats. Perfusion of the hearts with ET-1 increased ERK-1 and ERK-2 phosphorylation both in ouabain-treated and in control rats, with a larger stimulatory effect in ouabain-treated animals. On the contrary, exposure of endothelium-free tail artery to ET-1 increased ERKs phosphorylation both in treated and untreated rats, but this effect was blunted in ouabain-treated rats. These findings demonstrate that ouabain treatment has opposite effects on basal and ET-1-induced ERKs phosphorylation in the heart and in the tail artery of the rat. |
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Authors:
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Giulio Ceolotto; Michelangelo Sartori; Italia Papparella; Marco Candiotto; Elisabetta Baritono; Amelia Filippelli; Gabriella Cargnelli; Sisto Luciani; Andrea Semplicini; Sergio Bova |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 41 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-03-26 Completed Date: 2003-10-14 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 553-61 Citation Subset: IM |
Affiliation:
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Departments of Clinical and Experimental Medicine, University of Padua, Padua, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / drug effects*, enzymology, physiology* Coronary Vessels / drug effects*, enzymology, physiology* Endothelin-1 / pharmacology* Male Mitogen-Activated Protein Kinases / biosynthesis* Ouabain / pharmacology* Rats Rats, Sprague-Dawley Tail / blood supply* |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 630-60-4/Ouabain; EC 2.7.11.24/Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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