Document Detail

Different effect of inhaled nitric oxide on yucatan micropig with and without congenital ventricular septal defect.
MedLine Citation:
PMID:  8870413     Owner:  NLM     Status:  MEDLINE    
A strain of Yucatan micropigs is known to have heritable ventricular septal defects (VSDs) and thus may develop overflow pulmonary hypertension. Since inhaled nitric oxide (NO) selectively dilates pulmonary vessels, we determined its hemodynamic and co-agulatory effects in this new animal model. Eight Yucatan micropigs were anesthetized with midazolam, piritramide (a synthetic opioid) and vecuronium bromide. The presence and the size of the VSD were determined by using transesophageal color flow Doppler echocardiography. Four animals showed VSDs of 1-2 mm size. Inhaled NO was then administered with increasing inspired concentrations of 0, 5, 10, 20, 40, 80 and again 0 ppm NO for 10-min periods. NO inhalation did not affect heart rate, right cardiac output, mean arterial pressure, pulmonary arterial wedge pressure, or central venous pressure. Inhaled NO in animals with proven VSDs decreased pulmonary artery pressure (PAP) in a dose dependent manner; 5 ppm NO reduced mean PAP from 25 +/- 2.3 mm Hg to 18 +/- 0.8 mm Hg (p < 0.05), while pulmonary vascular resistance (PVR) decreased from 954 +/- 143 s-5 to 661 +/- 88 (p < 0.01) at the same dose. The maximum reduction in mean PAP and PVR occurred when 80 ppm NO was inhaled. Yucatan micropigs without VSDs did not respond hemodynamically to NO inhalation. Methemoglobin levels remained unchanged during the entire study. Platelet function was assessed according to the method of BREDDIN and BORN (BORN 1962). Initial aggregation and slope were affected when NO inhalation commenced. Yucatan micropigs with VSDs may represent a suitable model for further research of the in vivo effects of inhaled NO.
J Motsch; J Weimann; R Ehehalt; B W Böttiger; H Jakob; P A Schnabel; M M Gebhard; E Martin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of experimental animal science     Volume:  38     ISSN:  0939-8600     ISO Abbreviation:  J. Exp. Anim. Sci.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9103426     Medline TA:  J Exp Anim Sci     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  28-44     Citation Subset:  IM    
Department of Anesthesiology, University of Heidelberg, Germany.
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MeSH Terms
Administration, Inhalation
Blood Pressure / drug effects,  physiology
Cardiac Output / drug effects,  physiology
Disease Models, Animal
Dose-Response Relationship, Drug
Echocardiography, Doppler, Color / veterinary
Heart Rate / drug effects,  physiology
Heart Septal Defects, Ventricular / blood,  physiopathology,  veterinary*
Hemodynamics / physiology
Nitric Oxide / administration & dosage,  pharmacology*
Platelet Aggregation / drug effects,  physiology
Pulmonary Wedge Pressure / drug effects,  physiology
Swine Diseases / blood,  congenital*,  physiopathology*
Swine, Miniature / blood,  physiology*
Vascular Resistance / drug effects,  physiology
Vasodilation / drug effects,  physiology
Reg. No./Substance:
10102-43-9/Nitric Oxide

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