| Different effect of high fat diet and physical exercise in the hippocampal signaling. | |
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MedLine Citation:
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PMID: 18034303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity is an epidemic disease that may affect brain function. The present study examined the effect of high fat diet (HF) and physical exercise on peripheral tissue and hippocampal signaling. CF-1 mice (n = 4, per cage) were divided into groups receiving high fat (HF) or control (CD) diets for 5 months, with or without voluntary exercise. Serum triacylglycerol, total cholesterol, HDLc, liver triacylglycerol and glycogen concentrations were evaluated (n = 6). Also, the phosphorylation state of the AKT --> ERK 1/2 --> CREB pathway (AKT, pAKTser473, ERK 1/2, pERK 1/2, CREB and pCREB, n = 4-6) was analyzed in the hippocampus. HF diet caused an increase in AKT phosphorylation at ser473 (P < 0.05), while exercise increased the phosphorylation of ERK 1/2 (P < 0.05) and CREB (P < 0.05). As expected, exercise reversed some of the harmful effects of HF, i.e., increased liver deposition of fat (P < 0.05) and fat gain in the abdominal region (P < 0.05). In conclusion, the effects of exercise and HF diet on brain signaling appear to affect the hippocampal AKT --> ERK 1/2 --> CREB pathway in independent ways: HF intake caused increased phosphorylation of AKTser473, while exercise increased ERK 1/2 --> CREB signaling. The physiological relevance of these findings in brain function remains to be elucidated. |
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Authors:
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Alexandre Pastoris Muller; Martín Cammarota; Marcelo de Oliveira Dietrich; Liane N Rotta; Luis Valmor Portela; Diogo Onofre Souza; Iván Izquierdo; Lia R M Bevilaqua; Marcos Luiz Santos Perry |
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Publication Detail:
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Type: Journal Article Date: 2007-11-22 |
Journal Detail:
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Title: Neurochemical research Volume: 33 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-03-20 Completed Date: 2008-08-11 Revised Date: 2008-08-14 |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
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Languages: eng Pagination: 880-5 Citation Subset: IM |
Affiliation:
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Departamento de Bioquímica, Programa de Pós-Graduação em Ciências Biológicas-Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Dietary Fats / administration & dosage* Glucose Tolerance Test Hippocampus / enzymology, physiology* Lipids / blood Liver / anatomy & histology MAP Kinase Signaling System Male Mice Organ Size Physical Conditioning, Animal* Signal Transduction* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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