Document Detail

Different distribution patterns of cerebral microbleeds in acute ischemic stroke patients with and without hypertension.
MedLine Citation:
PMID:  19729926     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cerebral microbleeds (CMBs) were found in patients with and without hypertension. We aimed to investigate different distribution patterns of CMBs in patients with and without hypertension. METHODS: We examined acute ischemic stroke patients using a standardized MRI protocol that included T(1), T(2) and gradient-echo T(2)*. Clinical and imaging characteristics were collected from all patients. RESULTS: Among 998 patients, CMBs were detected in 273 patients (27.3%). Of these, 62 did not have hypertension (22.7%). The incidence of CMBs among patients without hypertension (62/335, 18.5%) was lower than among those with hypertension (211/663, 31.8%; p < 0.01). The location of CMBs in patients without hypertension was limited to the cortical-subcortical (CSC) region in 40.3% (25/62) compared to 20.4% of those with hypertension (43/211; p = 0.01). No significant difference was found between CMB locations within the intra-CSC region in both groups. The severity of white matter changes and systolic blood pressure on admission were found to be independent predictors for CMBs in patients without hypertension. CONCLUSIONS: CMBs in patients with and without hypertension have different distribution patterns and may have a different pathogenesis. Blood pressure controlling is important in both groups because systolic blood pressure is an independent predictor of CMBs in patients without hypertension.
Jian Sun; Yannie Oi Yan Soo; Wynnie Wai Man Lam; Ka Sing Wong; Jin Sheng Zeng; Yu Hua Fan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-29
Journal Detail:
Title:  European neurology     Volume:  62     ISSN:  1421-9913     ISO Abbreviation:  Eur. Neurol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-09     Completed Date:  2009-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  298-303     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Guangzhou, PR China.
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MeSH Terms
Brain Mapping
Cerebral Cortex / blood supply,  pathology,  physiopathology*
Cerebral Hemorrhage / complications*,  pathology,  physiopathology*
Cerebral Infarction / complications*,  pathology,  physiopathology*
Cerebrovascular Circulation
Hypertension / complications*,  physiopathology*
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Patient Selection
Regression Analysis

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