Document Detail


Different disparities of gender and race among the thrombotic thrombocytopenic purpura and hemolytic-uremic syndromes.
MedLine Citation:
PMID:  20799358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS) represent multiple disorders with diverse etiologies. We compared the gender and race of 335 patients enrolled in the Oklahoma TTP-HUS Registry across 21 years for their first episode of TTP or HUS to appropriate control groups. The relative frequency of women and white race among patients with TTP-HUS-associated with a bloody diarrhea prodrome and the relative frequency of women with quinine-associated TTP-HUS were significantly greater than their control populations. The relative frequency of women and black race among patients with idiopathic TTP and TTP-associated with severe ADAMTS13 deficiency was significantly greater than their control populations. The relative frequency of black race among patients who had systemic lupus erythematosus (SLE) preceding TTP was significantly greater than among a population of patients with SLE, and the relative frequency of black race among patients with other autoimmune disorders preceding TTP was significantly greater than their control population. No significant gender or race disparities were present among patients with hematopoietic stem cell transplantation-associated thrombotic microangiopathy, TTP associated with pregnancy, or TTP associated with drugs other than quinine. The validity of these observations is supported by the enrollment of all consecutive patients across 21 years from a defined geographic region, without selection or referral bias. These observations of different gender and race disparities among the TTP-HUS syndromes suggest the presence of different risk factors and may serve as starting points for novel investigations of pathogenesis.
Authors:
Deirdra R Terrell; Sara K Vesely; Johanna A Kremer Hovinga; Bernhard Lämmle; James N George
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hematology     Volume:  85     ISSN:  1096-8652     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-26     Completed Date:  2010-12-10     Revised Date:  2013-03-28    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  844-7     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley-Liss, Inc.
Affiliation:
Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126-0901, USA. deirdra-terrell@ouhsc.edu
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MeSH Terms
Descriptor/Qualifier:
ADAM Proteins / deficiency
African Americans
Age Distribution
Case-Control Studies
Continental Population Groups
Diarrhea
Female
Hemolytic-Uremic Syndrome / epidemiology*,  etiology
Humans
Lupus Erythematosus, Systemic / complications
Male
Oklahoma / epidemiology,  ethnology
Pregnancy
Purpura, Thrombotic Thrombocytopenic / epidemiology*,  etiology
Quinine / adverse effects
Sex Factors
Grant Support
ID/Acronym/Agency:
1U01HL72283-07S1/HL/NHLBI NIH HHS; U01 HL072283/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
130-95-0/Quinine; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human
Comments/Corrections

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