Document Detail


Different diagnostic power of anti-Mullerian hormone in evaluating women with polycystic ovaries with and without hyperandrogenism.
MedLine Citation:
PMID:  22886405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of this study is to compare the secretory profiles and diagnostic power of anti-Mullerian hormone (AMH) for the PCOS patient with and without hyperandrogenism.
METHODS: One hundred and thirty-one PCOS patients with oligomenorrhea or amenorrhea were recruited into the study. Sixty-two and sixty-nine patients had and did not have hyperandrogenism (HA+) hyperandrogenism (HA-), respectively. Sera were collected for determining the levels of AMH, basal sexual hormones, glucose and lipid metabolic indicators.
RESULTS: The AMH serum levels of PCOS patients were significantly higher than the control group, with the highest AMH serum level in the HA+ group. The cut-off value for predicting PCOS patients of all types was 3.92 ng/mL, with a sensitivity of 65 %, and specificity of 62 %. The cut-off value for predicting PCOS patients in the HA+ group was 4.23 ng/mL, with a sensitivity of 82 %, and specificity of 64 %. The cut-off value for predicting PCOS patients in the HA- group was 3.76 ng/mL, with a sensitivity of 64 %, and specificity of 62 %. In the HA+ group, AMH was negatively associated with FSH and positively associated with LH. In the HA- group, AMH was negatively associated with HDL and positively associated with BMI, fasting glucose and LDL.
CONCLUSIONS: AMH is only suitable for predicting the PCOS patients with hyperandrogenism. The diagnostic power of AMH is limited when used to predict patients without hyperandrogenism. It reflects the differences in pathophysiology and severity of disrupted folliculogenesis between the two subtypes.
Authors:
Yi Li; Yun Ma; Xianghong Chen; Wenjun Wang; Yu Li; Qingxun Zhang; Dongzi Yang
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-11
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-05-03     Revised Date:  2013-10-10    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1147-51     Citation Subset:  IM    
Affiliation:
Center for Reproductive Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Mullerian Hormone / blood*
Blood Glucose / analysis
Body Mass Index
Case-Control Studies
Female
Follicle Stimulating Hormone / blood
Humans
Hyperandrogenism / blood*
Lipids / blood
Luteinizing Hormone / blood
Oligomenorrhea / etiology
Polycystic Ovary Syndrome / blood*,  complications,  physiopathology
Predictive Value of Tests
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Lipids; 80497-65-0/Anti-Mullerian Hormone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone
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