Document Detail


Different desipramine-sensitive pulmonary removals of plasma epinephrine and norepinephrine in dogs.
MedLine Citation:
PMID:  1550259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lungs are an important site for the clearance of norepinephrine from the circulation, but the mechanism of removal and its importance for clearance of epinephrine require clarification. In the present study, 3H-labeled epinephrine and norepinephrine were infused intravenously into anesthetized dogs, and blood samples were taken from the pulmonary artery and aorta to compare pulmonary extractions of both catecholamines before and after administration of the neuronal uptake blocking drug, desipramine. Circulating [3H]norepinephrine and [3H]-epinephrine were both extracted by the lungs, but fractional extraction of [3H]epinephrine (8.1 +/- 1.1%) was half that of [3H]norepinephrine (16.9 +/- 1.9%). Pulmonary extractions of both catecholamines were completely blocked by desipramine. Desipramine-sensitive removal accounted for a tenth of the total body extraction of [3H]epinephrine and a third that of [3H]norepinephrine. Pulmonary removal of [3H]epinephrine was 14% that of the total body clearance, whereas pulmonary removal of [3H]norepinephrine was 25% that of the total body clearance. The study showed the following: removal of catecholamines by the canine lung in vivo is by desipramine-sensitive uptake; uptake is half as efficient for epinephrine as norepinephrine: and, pulmonary removal contributes importantly to the desipramine-sensitive component of total body catecholamine clearance.
Authors:
G Eisenhofer; J J Smolich; M D Esler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  262     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-23     Completed Date:  1992-04-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  L360-5     Citation Subset:  IM    
Affiliation:
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / physiology
Desipramine / pharmacology*
Dogs
Epinephrine / blood,  metabolism*
Female
Kinetics
Lung / drug effects,  metabolism*
Male
Norepinephrine / blood,  metabolism*
Pulmonary Artery / physiology
Pulmonary Circulation
Chemical
Reg. No./Substance:
50-47-5/Desipramine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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