| Different degrees of vascularization and their relationship to the expression of vascular endothelial growth factor, placental growth factor, angiopoietins, and their receptors in first-trimester decidual tissues. | |
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MedLine Citation:
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PMID: 17383647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate vascular adaptation to implantation by studying vascularization and angiogenic factors in the decidua basalis (DB), decidua parietalis, and decidual secretory endometrium of first-trimester pregnancies. Comparison of these tissues provides information about the regulation of vascularization by pregnancy-induced hormones and/or the extravillous trophoblast (EVT). DESIGN: Prospective study. SETTING: Leids University Medical Center (LUMC). PATIENT(S): Women (n = 32) undergoing voluntarily first-trimester termination of pregnancy. INTERVENTION(S): Decidual samples from vacuum-aspiration. MAIN OUTCOME MEASURE(S): Evaluation of vascularization, determined by CD34 immunohistochemistry, and vascular endothelial growth factor-A, placental growth factor (PlGF), vascular endothelial growth factor receptor 1 (Flt-1), vascular endothelial growth factor receptor 2, angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and TIE-2 protein and messenger RNA (mRNA) expression, determined by reverse transcriptase-polymerase chain reaction and immunohistochemistry, in serial paraffin sections. RESULT(S): Pregnancy-induced hormones and EVT influence vascularization by enhancing the vascular and luminal surface, and by reducing vessel density at the implantation site. These changes correlate with differences in gene and protein expression. Placental growth factor mRNA and PlGF and Flt-1 protein expressions were elevated in DB under the influence of EVT. In addition, the angiopoietins were differentially expressed, in favor of Ang-2, in DB. CONCLUSION(S): The EVT and pregnancy-induced hormones might be associated with the regulation of vascularization and the expression of angiogenic factors in decidua. The induction of PlGF and Flt-1, and the Ang-2:Ang-1 ratio in DB, suggest that these factors play a role in regulating angiogenesis at the implantation site. |
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Authors:
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Margreet Plaisier; Sharon Rodrigues; Florian Willems; Pieter Koolwijk; Victor W M van Hinsbergh; Frans M Helmerhorst |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-03-26 |
Journal Detail:
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Title: Fertility and sterility Volume: 88 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-06 Completed Date: 2007-07-31 Revised Date: 2009-11-25 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 176-87 Citation Subset: IM |
Affiliation:
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Department of Biomedical Research, TNO-Quality of Life, Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiopoietins / biosynthesis*, genetics Endometrium / blood supply*, metabolism Female Gene Expression Regulation / physiology Humans Pregnancy Pregnancy Proteins / biosynthesis*, genetics Pregnancy Trimester, First / genetics, metabolism* Prospective Studies Receptors, Vascular Endothelial Growth Factor / biosynthesis*, genetics Vascular Endothelial Growth Factor A / biosynthesis*, genetics |
| Chemical | |
Reg. No./Substance:
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0/Angiopoietins; 0/Pregnancy Proteins; 0/Vascular Endothelial Growth Factor A; 144589-93-5/placenta growth factor; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor |
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