| Different contribution of the lateral bed nucleus of the stria terminalis in intrahippocampal neostigmine-induced elevation of plasma glucose and adrenocorticotropic hormone in free moving rats. | |
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MedLine Citation:
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PMID: 20010499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In our previous study, a lesion in the lateral bed nucleus of the stria terminalis (BNSTL) was found to significantly attenuate the elevation of adrenocorticotropic hormone (ACTH) in plasma during microinjectin of neostigmine, an inhibitor of acetylcholine esterase, into the rat hippocampus. The current study was designed to examine the role of the BNSTL in regulation of blood glucose elevation induced by hippocampal neostigmine injection. MATERIALS AND METHODS: Ibotenic acid (15 microg/microl) was stereotaxically bilaterally injected into the BNSTL of rats. Two weeks after the injections, neostigmine methylsulfate (sigma, 5 x 10-8 mol) was microinjected into the rat hippocampus in a volume of 1 microl for 1 min using a CMA/100 microinjection pump. Plasma ACTH and glucose concentrations were examined using radioimmunoassay and immobilized enzyme casing/H2O2 method techniques, respectively. RESULTS: Compared with sham-operated control rats, rats with BNSTL lesions produced by ibotenic acid showed significantly attenuated the elevations of plasma ACTH evoked by the microinjection of neostigmine into the hippocampus. However, no significant difference of blood glucose in response to the injection was observed between the BNSTL-lesioned rats and controls. CONCLUSION: The results of the present study indicate that the BNSTL plays a role in ACTH regulation and not in blood glucose regulation when the hippocampal cholinergic system is activated. |
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Authors:
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Waner Zhu; Jiucai Cui; Wenqian Wang; Rong Zhang; Hiroyuki Umegaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuro endocrinology letters Volume: 30 ISSN: 0172-780X ISO Abbreviation: Neuro Endocrinol. Lett. Publication Date: 2009 |
Date Detail:
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Created Date: 2010-01-13 Completed Date: 2010-03-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008373 Medline TA: Neuro Endocrinol Lett Country: Sweden |
Other Details:
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Languages: eng Pagination: 511-4 Citation Subset: IM |
Affiliation:
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Department of Medical Psychology, Zhejiang University Graduate School of Medicine, Hangzhou, 310058, China. waner_zhu@yahoo.com.cn |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood* Animals Blood Glucose / drug effects*, metabolism Cholinergic Fibers / drug effects, physiology Cholinesterase Inhibitors / pharmacology Hippocampus / cytology*, drug effects, physiology* Male Microinjections Motor Activity Neostigmine / pharmacology Neural Pathways Rats Rats, Wistar Septal Nuclei / cytology*, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cholinesterase Inhibitors; 59-99-4/Neostigmine; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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