Document Detail

Different contribution of the lateral bed nucleus of the stria terminalis in intrahippocampal neostigmine-induced elevation of plasma glucose and adrenocorticotropic hormone in free moving rats.
MedLine Citation:
PMID:  20010499     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In our previous study, a lesion in the lateral bed nucleus of the stria terminalis (BNSTL) was found to significantly attenuate the elevation of adrenocorticotropic hormone (ACTH) in plasma during microinjectin of neostigmine, an inhibitor of acetylcholine esterase, into the rat hippocampus. The current study was designed to examine the role of the BNSTL in regulation of blood glucose elevation induced by hippocampal neostigmine injection. MATERIALS AND METHODS: Ibotenic acid (15 microg/microl) was stereotaxically bilaterally injected into the BNSTL of rats. Two weeks after the injections, neostigmine methylsulfate (sigma, 5 x 10-8 mol) was microinjected into the rat hippocampus in a volume of 1 microl for 1 min using a CMA/100 microinjection pump. Plasma ACTH and glucose concentrations were examined using radioimmunoassay and immobilized enzyme casing/H2O2 method techniques, respectively. RESULTS: Compared with sham-operated control rats, rats with BNSTL lesions produced by ibotenic acid showed significantly attenuated the elevations of plasma ACTH evoked by the microinjection of neostigmine into the hippocampus. However, no significant difference of blood glucose in response to the injection was observed between the BNSTL-lesioned rats and controls. CONCLUSION: The results of the present study indicate that the BNSTL plays a role in ACTH regulation and not in blood glucose regulation when the hippocampal cholinergic system is activated.
Waner Zhu; Jiucai Cui; Wenqian Wang; Rong Zhang; Hiroyuki Umegaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  30     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2009  
Date Detail:
Created Date:  2010-01-13     Completed Date:  2010-03-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  511-4     Citation Subset:  IM    
Department of Medical Psychology, Zhejiang University Graduate School of Medicine, Hangzhou, 310058, China.
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MeSH Terms
Adrenocorticotropic Hormone / blood*
Blood Glucose / drug effects*,  metabolism
Cholinergic Fibers / drug effects,  physiology
Cholinesterase Inhibitors / pharmacology
Hippocampus / cytology*,  drug effects,  physiology*
Motor Activity
Neostigmine / pharmacology
Neural Pathways
Rats, Wistar
Septal Nuclei / cytology*,  physiology*
Reg. No./Substance:
0/Blood Glucose; 0/Cholinesterase Inhibitors; 59-99-4/Neostigmine; 9002-60-2/Adrenocorticotropic Hormone

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