Document Detail

Different clinical and coronary angiographic findings according to ratios of total cholesterol to high-density lipoprotein cholesterol during the acute phase of myocardial infarction.
MedLine Citation:
PMID:  15242074     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Several pathological studies have shown that a higher ratio of the serum total cholesterol concentration to the high-density lipoprotein cholesterol concentration (TC/HDL-C ratio) is associated with plaque rupture in patients with acute coronary syndromes. We examined the relationship between the serum total cholesterol concentration and the TC/HDL-C ratio, and clinical and angiographic findings in patients with first acute myocardial infarction. METHODS: Two hundred eighty patients were classified into quartiles according to the TC/HDL-C ratio measured within 24 hr from symptom onset: 70 patients in the first quartile (group L: mean TC/HDL-C ratio, 3.0), 140 in the second and third quartiles (group M: mean TC/HDL-C ratio, 4.6), and 70 in the fourth quartile (group H: mean TC/HDL-C ratio, 7.5). RESULTS: There were no differences among the three groups with regard to sex, diabetes mellitus or hypertension. Patients in group L were older (66 +/- 9 vs 60 +/- 11, 56 +/- 10 years, p < 0.01) and had a higher incidence of stable angina before acute myocardial infarction (26% vs 14%, 10%, p < 0.05) than in patients groups M and H. Although coronary angiograms revealed no difference in the number of diseased vessels among the three groups, extent index indicating the proportion of each coronary segment that appears angiographically abnormal was lowest in group L (0.7 +/- 0.5), followed by group M (1.3 +/- 0.6), and high- est in group H ( 1.7 +/- 0.6, p < 0.01). The number of segments with calcification and the incidence of calcification in the culprit lesion were higher in group L than in groups M and H. CONCLUSIONS: Our findings suggest that the clinical presentations and angiographic appearances differ according to the TC/HDL-C ratio in the acute phase of acute myocardial infarction.
Masami Kosuge; Kazuo Kimura; Toshiyuki Ishikawa; Tomoaki Shimizu; Teruyasu Sugano; Shinichi Sumita; Kiyoshi Hibi; Takeshi Takamura; Noritaka Toda; Masahiko Kanna; Kengo Tsukahara; Jun Okuda; Yoshio Tahara; Naoki Nozawa; Eri Furukawa; Satoshi Umemura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiology     Volume:  43     ISSN:  0914-5087     ISO Abbreviation:  J Cardiol     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-09     Completed Date:  2004-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  251-8     Citation Subset:  IM    
Division of Cardiology, Yokohama City University Medical Center, Urafune-cho 4-57, Minami-ku, Yokohama 232-0024.
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MeSH Terms
Acute-Phase Reaction
Cholesterol / blood*
Cholesterol, HDL / blood*
Coronary Angiography*
Coronary Vessels / pathology
Middle Aged
Myocardial Infarction / blood*,  radiography*
Reg. No./Substance:
0/Cholesterol, HDL; 57-88-5/Cholesterol

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