Document Detail

Different cardiac loading conditions and haemodynamic monitoring in animal models.
MedLine Citation:
PMID:  22428759     Owner:  NLM     Status:  In-Data-Review    
Objective: To develop models of various cardiac loading conditions in an experimental study. Materials and methods: A total of 78 piglets, average weight 24 kg were divided into 4 groups under different cardiac loading conditions: Group A were spontaneously breathing pigs without haemodynamic changes, Group B were ventilated animals with increased left ventricular afterload, Group C ventilated with increased right ventricular preload and Group D ventilated with increased afterload of both heart ventricles. Haemodynamic parameters were invasively measured at 60 and 120 minutes. Results: Groups B, C and D demonstrated higher preload of both ventricles, compared with Group A. Group C demonstrated higher preload and afterload of both ventricles in comparison with Groups B and D. Conclusion: Haemodynamic measured data confirmed the expected changes in cardiac loading and corresponded to human clinical situations. These models may be used for future experimental haemodynamic studies (Tab. 1, Fig. 3, Ref. 8). Keywords: pulmonary artery thermodilution, cardiac output, piglets.
J Kobr; V Treska; J Molacek; V Kuntscher; V Liska; J Koppl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  113     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  131-4     Citation Subset:  IM    
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