Document Detail


Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation.
MedLine Citation:
PMID:  9770722     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiological studies have suggested that the concentration and composition of fecal bile acids are important determining factors in the etiology of colon cancer. However, the mechanism by which these compounds influence tumor development is not understood. To begin to elucidate their mechanism of action, four bile acids, cholic acid, chenodeoxycholic acid, deoxycholic acid (DCA), and ursodeoxycholic acid, were examined for their effects on the growth of several different tumor cell lines. We found that incubating cells with chenodeoxycholic acid or DCA caused morphological changes, seen by electron and light microscopy, that were characteristic of apoptosis, whereas incubating cells with ursodeoxycholic acid inhibited cell proliferation but did not induce apoptosis. Cholic acid had no discernible effect on cells. Notably, the apoptosis induced by DCA could be suppressed by inhibiting protein kinase C activity with calphostin C. These results indicate that different bile acids exhibit distinct biological activities and suggest that the cytotoxicity reported for DCA may be due to its capacity to induce apoptosis via a protein kinase C-dependent signaling pathway.
Authors:
J D Martinez; E D Stratagoules; J M LaRue; A A Powell; P R Gause; M T Craven; C M Payne; M B Powell; E W Gerner; D L Earnest
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nutrition and cancer     Volume:  31     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  1998  
Date Detail:
Created Date:  1998-12-07     Completed Date:  1998-12-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  111-8     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, Arizona Cancer Center, Tucson 85724, USA. JMARTINEZ@AZCC.ARIZONA.EDU
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MeSH Terms
Descriptor/Qualifier:
Anticarcinogenic Agents / metabolism*
Apoptosis
Bile Acids and Salts / metabolism*
Carcinogens / adverse effects*
Cell Division
Chenodeoxycholic Acid / metabolism
Cholic Acid / metabolism
Colorectal Neoplasms, Hereditary Nonpolyposis / metabolism*
Deoxycholic Acid / adverse effects*
Humans
Tumor Cells, Cultured / metabolism
Ursodeoxycholic Acid / metabolism*
Grant Support
ID/Acronym/Agency:
CA-23074/CA/NCI NIH HHS; ES-06694/ES/NIEHS NIH HHS; P01-CA-72008/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Bile Acids and Salts; 0/Carcinogens; 128-13-2/Ursodeoxycholic Acid; 474-25-9/Chenodeoxycholic Acid; 81-25-4/Cholic Acid; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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