| Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation. | |
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MedLine Citation:
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PMID: 9770722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiological studies have suggested that the concentration and composition of fecal bile acids are important determining factors in the etiology of colon cancer. However, the mechanism by which these compounds influence tumor development is not understood. To begin to elucidate their mechanism of action, four bile acids, cholic acid, chenodeoxycholic acid, deoxycholic acid (DCA), and ursodeoxycholic acid, were examined for their effects on the growth of several different tumor cell lines. We found that incubating cells with chenodeoxycholic acid or DCA caused morphological changes, seen by electron and light microscopy, that were characteristic of apoptosis, whereas incubating cells with ursodeoxycholic acid inhibited cell proliferation but did not induce apoptosis. Cholic acid had no discernible effect on cells. Notably, the apoptosis induced by DCA could be suppressed by inhibiting protein kinase C activity with calphostin C. These results indicate that different bile acids exhibit distinct biological activities and suggest that the cytotoxicity reported for DCA may be due to its capacity to induce apoptosis via a protein kinase C-dependent signaling pathway. |
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Authors:
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J D Martinez; E D Stratagoules; J M LaRue; A A Powell; P R Gause; M T Craven; C M Payne; M B Powell; E W Gerner; D L Earnest |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nutrition and cancer Volume: 31 ISSN: 0163-5581 ISO Abbreviation: Nutr Cancer Publication Date: 1998 |
Date Detail:
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Created Date: 1998-12-07 Completed Date: 1998-12-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 111-8 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Arizona Cancer Center, Tucson 85724, USA. JMARTINEZ@AZCC.ARIZONA.EDU |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticarcinogenic Agents
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metabolism* Apoptosis Bile Acids and Salts / metabolism* Carcinogens / adverse effects* Cell Division Chenodeoxycholic Acid / metabolism Cholic Acid / metabolism Colorectal Neoplasms, Hereditary Nonpolyposis / metabolism* Deoxycholic Acid / adverse effects* Humans Tumor Cells, Cultured / metabolism Ursodeoxycholic Acid / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA-23074/CA/NCI NIH HHS; ES-06694/ES/NIEHS NIH HHS; P01-CA-72008/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Bile Acids and Salts; 0/Carcinogens; 128-13-2/Ursodeoxycholic Acid; 474-25-9/Chenodeoxycholic Acid; 81-25-4/Cholic Acid; 83-44-3/Deoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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