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Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents.
MedLine Citation:
PMID:  21403826     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Adipose tissue metabolism is closely linked to insulin resistance, and differential fat distributions are associated with disorders like hypertension, diabetes, and cardiovascular disease. Adipose tissues vary in their impact on metabolic risk due to diverse gene expression profiles, leading to differences in lipolysis and in the production and release of adipokines and cytokines, thereby affecting the function of other tissues. In this paper, the roles of the various adipose tissues in obesity are summarized, with particular focus on mitochondrial function. In addition, we discuss how a functionally mitochondrial-targeted compound, the modified fatty acid tetradecylthioacetic acid (TTA), can influence mitochondrial function and decrease the size of specific fat depots.
Authors:
Bodil Bjørndal; Lena Burri; Vidar Staalesen; Jon Skorve; Rolf K Berge
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Publication Detail:
Type:  Journal Article     Date:  2011-02-15
Journal Detail:
Title:  Journal of obesity     Volume:  2011     ISSN:  2090-0716     ISO Abbreviation:  J Obes     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-15     Completed Date:  2011-07-14     Revised Date:  2011-07-26    
Medline Journal Info:
Nlm Unique ID:  101526295     Medline TA:  J Obes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  490650     Citation Subset:  -    
Affiliation:
Institute of Medicine, University of Bergen, N 5021 Bergen, Norway.
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