| Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents. | |
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MedLine Citation:
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PMID: 21403826 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Adipose tissue metabolism is closely linked to insulin resistance, and differential fat distributions are associated with disorders like hypertension, diabetes, and cardiovascular disease. Adipose tissues vary in their impact on metabolic risk due to diverse gene expression profiles, leading to differences in lipolysis and in the production and release of adipokines and cytokines, thereby affecting the function of other tissues. In this paper, the roles of the various adipose tissues in obesity are summarized, with particular focus on mitochondrial function. In addition, we discuss how a functionally mitochondrial-targeted compound, the modified fatty acid tetradecylthioacetic acid (TTA), can influence mitochondrial function and decrease the size of specific fat depots. |
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Authors:
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Bodil Bjørndal; Lena Burri; Vidar Staalesen; Jon Skorve; Rolf K Berge |
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Publication Detail:
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Type: Journal Article Date: 2011-02-15 |
Journal Detail:
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Title: Journal of obesity Volume: 2011 ISSN: 2090-0716 ISO Abbreviation: J Obes Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-15 Completed Date: 2011-07-14 Revised Date: 2011-07-26 |
Medline Journal Info:
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Nlm Unique ID: 101526295 Medline TA: J Obes Country: United States |
Other Details:
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Languages: eng Pagination: 490650 Citation Subset: - |
Affiliation:
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Institute of Medicine, University of Bergen, N 5021 Bergen, Norway. |
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