| Different actions of gamma-hydroxybutyrate: a critical outlook. | |
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MedLine Citation:
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PMID: 14579796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gamma-hydroxybutyrate acid (GHB) is a naturally occurring analog of GABA in the mammalian brain and can be therapeutically used for basic sedation in intensive care units. Although its application is discussed controversially, GHB is suspected to protect neuronal tissue against ischemic damage. GHB was tested for an acute effect on electrophysiologic parameters of guinea pig hippocampal tissues exposed to ischemic conditions. With application of 0.5 mM GHB, an acute protective effect was observed. The aim of the present paper is to discuss our experimental results as well as pathophysiological mechanisms of GHB and its clinical applicability. |
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Authors:
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Christoph Greiner; Jens-Eric Röhl; Ali-Gorji; Hansdetlef Wassmann; Erwin-Josef Speckmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Neurological research Volume: 25 ISSN: 0161-6412 ISO Abbreviation: Neurol. Res. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-28 Completed Date: 2003-12-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: England |
Other Details:
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Languages: eng Pagination: 759-63 Citation Subset: IM |
Affiliation:
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Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Münster, Albert-Schweitzer-Str. 33, 48149 Münster, Germany. greiner@uni-muenster.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, metabolism Humans Hypnotics and Sedatives / chemistry, metabolism, pharmacology Sleep / drug effects, physiology Sodium Oxybate / chemistry, metabolism*, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 502-85-2/Sodium Oxybate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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