Document Detail

Different actions of gamma-hydroxybutyrate: a critical outlook.
MedLine Citation:
PMID:  14579796     Owner:  NLM     Status:  MEDLINE    
Gamma-hydroxybutyrate acid (GHB) is a naturally occurring analog of GABA in the mammalian brain and can be therapeutically used for basic sedation in intensive care units. Although its application is discussed controversially, GHB is suspected to protect neuronal tissue against ischemic damage. GHB was tested for an acute effect on electrophysiologic parameters of guinea pig hippocampal tissues exposed to ischemic conditions. With application of 0.5 mM GHB, an acute protective effect was observed. The aim of the present paper is to discuss our experimental results as well as pathophysiological mechanisms of GHB and its clinical applicability.
Christoph Greiner; Jens-Eric Röhl; Ali-Gorji; Hansdetlef Wassmann; Erwin-Josef Speckmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neurological research     Volume:  25     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-28     Completed Date:  2003-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  759-63     Citation Subset:  IM    
Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Münster, Albert-Schweitzer-Str. 33, 48149 Münster, Germany.
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MeSH Terms
Brain / drug effects,  metabolism
Hypnotics and Sedatives / chemistry,  metabolism,  pharmacology
Sleep / drug effects,  physiology
Sodium Oxybate / chemistry,  metabolism*,  pharmacology*
Reg. No./Substance:
0/Hypnotics and Sedatives; 502-85-2/Sodium Oxybate

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