Document Detail


Different Treatment Interventions Affect Plasma NT-ProBNP Levels and Early Exercise Tolerance in Patients with Acute ST-Segment Elevation Myocardial Infarction.
MedLine Citation:
PMID:  22437216     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective: The aim of this study was to investigate the effect of different treatment interventions on plasma N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) levels and early exercise tolerance in patients with acute ST-segment elevation myocardial infarction. Methods: 146 consecutive patients with ST-segment elevation myocardial infarction who received emergency percutaneous coronary intervention (PCI) (n = 55), elective PCI (n = 47), or drug treatment (n = 44) were included. Plasma NT-proBNP levels and left ventricular ejection fractions (LVEFs) were measured before the treatment intervention and at 1 week and 1 month afterward. An exercise stress test was performed 1 month after the intervention, and the occurrences of major adverse cardiac events (MACE) were recorded at the 1-month follow-up. Results: Compared with the elective PCI and drug treatment groups, at 1 week and 1 month after the intervention, the emergency PCI group's plasma NT-proBNP levels were significantly lower, and the group's LVEFs were significantly higher (all P < 0.05). There was a significantly negative correlation between plasma NT-proBNP levels and LVEFs in each group (all P < 0.05). The positive exercise stress testing rates were 13.0%, 32.6%, and 38.6% in the emergency PCI, elective PCI, and drug treatment groups, respectively (P < 0.05). The occurrences of MACE in the emergency PCI, elective PCI, and drug treatment groups were 34.5%, 59.5%, and 65.9%, respectively (P < 0.05). Conclusion: Emergency PCI resulted in lower plasma NT-proBNP levels, lower MACE incidence, higher LVEFs, and better early exercise tolerance compared with elective PCI or drug treatment, indicating that lower plasma NT-proBNP levels predicted a better prognosis.
Authors:
Xiao-Lin Wu; Rui Zhu; Hong Jiang; Bin Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medicine     Volume:  124     ISSN:  1941-9260     ISO Abbreviation:  Postgrad Med     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401147     Medline TA:  Postgrad Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-63     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, Xiangyang Central Hospital, Xiangyang, Hubei Province, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China. wxling.23@163.com.
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