| Different Treatment Interventions Affect Plasma NT-ProBNP Levels and Early Exercise Tolerance in Patients with Acute ST-Segment Elevation Myocardial Infarction. | |
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MedLine Citation:
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PMID: 22437216 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: The aim of this study was to investigate the effect of different treatment interventions on plasma N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) levels and early exercise tolerance in patients with acute ST-segment elevation myocardial infarction. Methods: 146 consecutive patients with ST-segment elevation myocardial infarction who received emergency percutaneous coronary intervention (PCI) (n = 55), elective PCI (n = 47), or drug treatment (n = 44) were included. Plasma NT-proBNP levels and left ventricular ejection fractions (LVEFs) were measured before the treatment intervention and at 1 week and 1 month afterward. An exercise stress test was performed 1 month after the intervention, and the occurrences of major adverse cardiac events (MACE) were recorded at the 1-month follow-up. Results: Compared with the elective PCI and drug treatment groups, at 1 week and 1 month after the intervention, the emergency PCI group's plasma NT-proBNP levels were significantly lower, and the group's LVEFs were significantly higher (all P < 0.05). There was a significantly negative correlation between plasma NT-proBNP levels and LVEFs in each group (all P < 0.05). The positive exercise stress testing rates were 13.0%, 32.6%, and 38.6% in the emergency PCI, elective PCI, and drug treatment groups, respectively (P < 0.05). The occurrences of MACE in the emergency PCI, elective PCI, and drug treatment groups were 34.5%, 59.5%, and 65.9%, respectively (P < 0.05). Conclusion: Emergency PCI resulted in lower plasma NT-proBNP levels, lower MACE incidence, higher LVEFs, and better early exercise tolerance compared with elective PCI or drug treatment, indicating that lower plasma NT-proBNP levels predicted a better prognosis. |
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Authors:
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Xiao-Lin Wu; Rui Zhu; Hong Jiang; Bin Li |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Postgraduate medicine Volume: 124 ISSN: 1941-9260 ISO Abbreviation: Postgrad Med Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401147 Medline TA: Postgrad Med Country: United States |
Other Details:
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Languages: eng Pagination: 58-63 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Xiangyang Central Hospital, Xiangyang, Hubei Province, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China. wxling.23@163.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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