| Different ELR (+) angiogenic CXC chemokine profiles in synovial fluid of patients with Beh?et's disease, familial Mediterranean fever, rheumatoid arthritis, and osteoarthritis. | |
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MedLine Citation:
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PMID: 15672235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to determine synovial levels of ELR (+) CXC chemokines, known to attract mainly neutrophils to inflamed tissues by binding the neutrophil chemokine receptors CXCR1 and CXCR2 and promoting neovascularization in patients with various inflammatory disorders. The study group consisted of 14 patients with Beh?et's disease and nine with familial Mediterranean fever. Fourteen patients with rheumatoid arthritis and 16 with osteoarthritis served as controls. Synovial chemokine levels were measured by two-step sandwich enzyme-linked immunosorbent assay, and significant differences were found in the various chemokines studied. In addition to its angiogenic properties, increased synovial levels of interleukin-8 by attraction of more neutrophils to synovial fluids might also be responsible for the acute synovitis in patients with Beh?et's disease. However, the absence of chronic changes with the eventual development of pannus and erosions might result from relatively lower expression of interleukin-8 and the transient, short-lived nature of the arthritis observed in these patients. |
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Authors:
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Hakan Erdem; Salih Pay; Muhittin Serdar; Ismail Sim?ek; Ayhan Din?; U?ur Mu?abak; Aysel Pekel; Mustafa Turan |
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Publication Detail:
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Type: Journal Article Date: 2004-11-03 |
Journal Detail:
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Title: Rheumatology international Volume: 26 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-12 Completed Date: 2006-09-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 162-7 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, G?lhane Military School of Medicine, Etlik, Ankara 06018, Turkey. herdem67@gata.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiogenesis Inhibitors / metabolism* Arthritis, Rheumatoid / metabolism* Behcet Syndrome / metabolism* Chemokine CXCL1 Chemokine CXCL5 Chemokines, CXC / metabolism* Familial Mediterranean Fever / metabolism* Female Humans Intercellular Signaling Peptides and Proteins / metabolism Interleukin-8 / metabolism Male Microtubule-Associated Proteins / metabolism Middle Aged Neovascularization, Pathologic / metabolism Osteoarthritis, Knee / metabolism* Synovial Fluid / cytology, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/CXCL1 protein, human; 0/CXCL5 protein, human; 0/Chemokine CXCL1; 0/Chemokine CXCL5; 0/Chemokines, CXC; 0/Intercellular Signaling Peptides and Proteins; 0/Interleukin-8; 0/Microtubule-Associated Proteins; 0/TUBGCP2 protein, human |
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