| Different determinants of improvement of early and late systolic mitral regurgitation contributed after cardiac resynchronization therapy. | |
| | |
MedLine Citation:
|
PMID: 20800439 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: Functional mitral regurgitation (MR) at different phases of the regurgitant period may respond differently to cardiac resynchronization therapy (CRT). The aims of this study were to examine the impact of CRT on the phasic changes of MR (early vs late systole) and to explore the mechanisms of such changes. METHODS: Instantaneous MR flow rate and total MR volume were evaluated in 60 patients who had more than mild functional MR before and 3 months after CRT. In addition, indices of global left ventricular (LV) remodeling, mitral deformation, and LV systolic dyssynchrony were assessed. RESULTS: CRT diminished MR volume (38 ± 18 vs 32 ± 20 mL) by reducing both the early (72 ± 47 vs 58 ± 48 mL/sec) and late (48 ± 42 vs 40 ± 42 mL/sec) systolic components (all p values < .01). In patients with ≥10% reductions in total MR volume but not in patients without this improvement, there were significant reductions in LV end-systolic volume, increases in LV +dP/dt, decreases in mitral valvular tenting, and improvements of systolic dyssynchrony at 3 months (all P values < .05). By multivariate regression, the reductions in LV end-systolic volume and tenting area were independent determinants of a reduction in total MR volume: the reductions in LV end-systolic volume and global dyssynchrony determined the reduction in early systolic MR, and the reductions in tenting area and global dyssynchrony determined reduction in late systolic MR. CONCLUSIONS: CRT decreases MR volume by reducing both early and late systolic MR. The determinants of the phasic improvement in functional MR are different. |
| | |
Authors:
|
Yu-Jia Liang; Qing Zhang; Jeffrey Wing-Hong Fung; Joseph Yat-Sun Chan; Gabriel Wai-Kwok Yip; Yat-Yin Lam; Alex Pui-Wai Lee; Cheuk-Man Yu |
Related Documents
:
|
18993159 - Effects of valve replacement for aortic stenosis on mitral regurgitation. 19692839 - Hippocampal mri volumetry at 3 tesla: reliability and practical guidance. 19001469 - Towards an accurate and robust method based on fuzzy logic principles for the reconstru... 9288189 - Hypertensive heart disease: quantitative evaluation of response to therapy with cine mr... 17974699 - Assessment of left ventricular mass and volumes by three-dimensional echocardiography i... 17950149 - Anatomically oriented right ventricular volume measurements with dynamic three-dimensio... 666279 - Benign cerebellar hemorrhages. 18311579 - Soft tissue morphometry of the malleus-incus complex from micro-ct imaging. 3975399 - Gastric interposition following transhiatal esophagectomy: ct evaluation. |
Publication Detail:
|
Type: Journal Article Date: 2010-08-30 |
Journal Detail:
|
Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 23 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
|
Languages: eng Pagination: 1160-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved. |
Affiliation:
|
Institute of Vascular Medicine, Li Ka Shing Institute of Health and Sciences, Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Translating shoulder computerized adaptive testing generated outcome measures into clinical practice...
Next Document: Advantage of right ventricular outflow tract pacing on cardiac function and coronary circulation in ...