| Differences in the vascular response to terbutaline in the native and transplanted rat pancreas. | |
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MedLine Citation:
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PMID: 8276038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Syngeneic pancreaticoduodenal transplantations were performed in Wistar-Furth rats. Fourteen days after implantation, blood perfusion of the whole native and transplanted pancreas, the pancreatic islets and the native and transplanted duodenum was measured with a microsphere technique 5 min after an intravenous injection of 0.5 ml of either saline (n = 6) or terbutaline (1 mg/kg BW; n = 9). Terbutaline decreased the mean arterial blood pressure by approximately 30% (p < 0.001). The substance also decreased the whole pancreatic blood flow of the native pancreas (p < 0.05), but not of the transplanted gland. However, the vascular conductance of the whole pancreas was unchanged after terbutaline administration in both the native and transplanted gland. Islet blood flow (p < 0.001) and islet vascular conductance (p < 0.01) were markedly decreased in the native pancreas. In the transplanted gland, there was, however, no change in islet vascular conductance and only a slight decrease in islet blood flow (p < 0.05). Both the native and transplanted duodenal blood flows were unaffected by terbutaline. One likely explanation for the different effects of terbutaline on the blood perfusion of the native and transplanted pancreas may be that the latter gland is devoid of any physiologically relevant exogenous innervation. |
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Authors:
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L Jansson; J Wahlberg; A Andersson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 25 ISSN: 0014-312X ISO Abbreviation: Eur Surg Res Publication Date: 1993 |
Date Detail:
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Created Date: 1994-02-10 Completed Date: 1994-02-10 Revised Date: 2006-11-30 |
Medline Journal Info:
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Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 383-9 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects Blood Pressure / drug effects Denervation Duodenum / blood supply, drug effects, transplantation Male Pancreas / blood supply*, drug effects*, innervation Pancreas Transplantation / physiology* Rats Rats, Inbred WF Terbutaline / pharmacology* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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23031-25-6/Terbutaline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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