| Differences in vascular effects and removal of endothelin-1 in human lung, brain, and skeletal muscle. | |
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MedLine Citation:
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PMID: 8119059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the effects and elimination of endothelin-1 in humans, an intravenous infusion of endothelin-1 (ET-1) (4 pmol kg-1 min-1 for 20 min) was given to 10 healthy volunteers. Arterial plasma endothelin-1 like immunoreactivity (ET-1-LI) increased eleven-fold. The fractional extraction of ET-1-LI was 41% and 30% across the pulmonary and skeletal muscle vascular beds, respectively. The lung eliminated almost half of the administered ET-1. No fractional extraction was found in the cerebral circulation. The pulmonary oxygen uptake (VO2) was increased slightly by endothelin-1. Across both the cerebral and skeletal muscle vascular beds the arterio-venous oxygen difference decreased (P < 0.05), suggesting vasodilation, the effect lasting up to 1 h after the end of endothelin-1 infusion in the cerebral circulation. Arterial-pulmonary artery oxygen difference increased by 20%. ET-1 infusion led to a decrease in heart rate (10%), cardiac output (14%) and stroke volume (8%) (all with P < 0.05) as well as a 7% increase in mean arterial blood pressure. Pulmonary and systemic vascular resistance increased by 67% and 25%, respectively (P < 0.05). These results demonstrate the regional differences in the removal of circulating endothelin-1, the lung being mainly responsible for the plasma elimination. Endothelin-1 seems to exert both vasoconstrictive and vasodilatory actions in humans, probably depending on differences in receptor populations and endothelium configuration in various vascular beds. |
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Authors:
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E Weitzberg; G Ahlborg; J M Lundberg |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical physiology (Oxford, England) Volume: 13 ISSN: 0144-5979 ISO Abbreviation: Clin Physiol Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-04-06 Completed Date: 1994-04-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309768 Medline TA: Clin Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 653-62 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Intensive Care, Karolinska Hospital, Stockholm, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / metabolism* Cardiac Output / drug effects Cerebrovascular Circulation / drug effects* Endothelins / metabolism, pharmacology* Hemodynamics / drug effects Humans Infusions, Intravenous Lung / metabolism* Male Muscles / blood supply*, metabolism Oxygen / blood Pulmonary Circulation / drug effects* Radioimmunoassay Regional Blood Flow / drug effects Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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