Document Detail


Differences in time to onset of smoking and nicotine dependence by race/ethnicity in a Midwestern sample of adolescents and young adults from a high risk family study.
MedLine Citation:
PMID:  22564873     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of this study was to determine whether race/ethnicity was associated with time to smoking initiation and time from first cigarette to onset of DSM-IV nicotine dependence (ND) after adjusting for familial and individual psychosocial risk factors.
METHODS: Cox proportional hazards models with time-dependent covariates were used to analyze data from 1376 offspring aged 12-33 years from 532 families at high risk for substance use problems due to paternal alcohol problems and 235 low risk families. Fifty-six percent of the sample self-identified as African-American (AA) and 44% were mainly of European descent.
RESULTS: Controlling for covariates, AAs began smoking at older ages (HR=0.58; 95% CI: 0.48-0.70) and had longer times between smoking initiation and onset of ND compared to non-AAs (HR=0.25, 95% CI: 0.16-0.39 for ND onset occurring <18 years and HR=0.49, 95% CI: 0.30-0.80 for ND onsets ≥ age 18). After additionally controlling for number of cigarettes smoked daily, the racial/ethnic effects for onset of ND were attenuated, but remained statistically significant for ND onset <18 (HR=0.34, 95% CI: 0.19-0.61); however, the estimate was no longer significant for later ND onset (HR=0.84, 95% CI: 0.50-1.41).
CONCLUSIONS: AA adolescents and young adults initiate smoking at older ages and have longer transition periods between initiation and onset of ND compared to non-AAs, even after controlling for many relevant psychiatric and psychosocial covariates; however, racial/ethnic differences in time to onset of nicotine dependence in late adolescence and young adulthood may be explained by differences in daily quantity smoked.
Authors:
Alexis E Duncan; Christina N Lessov-Schlaggar; Carolyn E Sartor; Kathleen K Bucholz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-05-06
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  125     ISSN:  1879-0046     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-14     Completed Date:  2012-12-27     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  140-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Americans
Age Factors
Age of Onset
Data Interpretation, Statistical
Diagnostic and Statistical Manual of Mental Disorders
Educational Status
Ethnic Groups
European Continental Ancestry Group
Family
Female
Humans
Longitudinal Studies
Male
Midwestern United States / epidemiology
Missouri / epidemiology
Proportional Hazards Models
Risk
Sex Factors
Smoking / epidemiology*
Socioeconomic Factors
Telephone
Tobacco Use Disorder / epidemiology*
Young Adult
Grant Support
ID/Acronym/Agency:
AA017921/AA/NIAAA NIH HHS; AA11998/AA/NIAAA NIH HHS; AA12640/AA/NIAAA NIH HHS; DA014363/DA/NIDA NIH HHS; DA027046/DA/NIDA NIH HHS; K01 DA027046/DA/NIDA NIH HHS; K08 AA017921/AA/NIAAA NIH HHS; P50 AA011998/AA/NIAAA NIH HHS; R01 AA012640/AA/NIAAA NIH HHS; R01 DA014363/DA/NIDA NIH HHS
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