| Differences in time course of myocardial mRNA expression in non-infarcted myocardium after myocardial infarction. | |
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MedLine Citation:
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PMID: 11005587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In non-infarcted myocardium after myocardial infarction, the change of cardiac phenotypic modulation of contractile protein, extracellular matrix and intracellular Ca2+ transport protein, such as sarcoplasmic reticulum Ca2+(SR-Ca2+)-ATPase, Na+-Ca2+ exchanger, have a important role during cardiac remodeling. However, the time course in this gene expression in the adjacent and remote left ventricular, or right ventricular myocardium after myocardial infarction has not been well examined. The purpose of this study was to examine the left ventricular function and regional cardiac gene expression after myocardial infarction. Myocardial infarction was produced in Wistar rats by the ligation of the left anterior descending coronary artery. After 3 weeks, 2 months and 4 months from myocardial infarction, we performed Doppler echocardiography and measured the systolic and diastolic function. Then, we analyzed the contractile protein, extracellular matrix and intracellular Ca2+ transport protein mRNAs of cardiac tissues in the adjacent and the remote noninfarcted myocardium, and right ventricular myocardium by Northern blot hybridization. Fractional shortening of infarcted heart progressively decreased. Peak early diastolic filling wave (E wave) velocity increased, and the deceleration rate of the E wave velocity was more rapid in myocardial infarction areas. Atrial filling wave (A wave) velocity decreased, resulting in a marked increase in the ratio of E wave to A wave velocity. Expression of myocardial alpha-skeletal actin, beta-MHC and ANP mRNA, or collagen I and III mRNA were higher at 3 weeks after myocardial infarction. SR Ca2+-ATPase mRNA in the adjacent non-infarcted myocardium was decreased at 2 months, and that in remote myocardium was decreased at 4 months after infarction. Na+-Ca2+ exchanger mRNA levels were increased at 3 weeks, but was decreased at 2 months in the adjacent non-infarcted myocardium and at 4 months in the remote myocardium. These findings suggest that the compensation for myocardial infarction by myocardial gene expression in non-infarcted myocardium may occur at an early phase after myocardial infarction, and myocardial dysfunction may begin from adjacent to remote non-infarcted myocardium during progressive cardiac remodeling. |
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Authors:
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T Omura; M Yoshiyama; K Takeuchi; A Hanatani; S Kim; K Yoshida; Y Izumi; H Iwao; J Yoshikawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Basic research in cardiology Volume: 95 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2001-01-11 Completed Date: 2001-01-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 316-23 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Natriuretic Factor / genetics Calcium-Transporting ATPases / genetics Collagen / genetics Echocardiography, Doppler Hemodynamics Male Myocardial Infarction / metabolism*, physiopathology Myocardium / metabolism* Myosin Heavy Chains / genetics RNA, Messenger / analysis* Rats Rats, Wistar Sodium-Calcium Exchanger / genetics Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Myosin Heavy Chains; 0/RNA, Messenger; 0/Sodium-Calcium Exchanger; 85637-73-6/Atrial Natriuretic Factor; 9007-34-5/Collagen; EC 3.6.1.8/Calcium-Transporting ATPases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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