Document Detail

Differences in systemic and myocardial blood acid-base status during cardiopulmonary resuscitation.
MedLine Citation:
PMID:  2707015     Owner:  NLM     Status:  MEDLINE    
Simultaneous arterial (aortic), mixed venous (pulmonary artery), and myocardial venous (great cardiac vein) blood gas and lactate concentrations were obtained in 12 dogs before and during cardiac arrest and CPR. We observed marked mixed venous and myocardial venous acidosis and increased PaCO2 but normal pHa and reduced PaCO2. Furthermore, the pH was significantly lower and the PCO2 significantly higher at the myocardial venous site compared to the mixed venous site, and marked myocardial lactate production occurred during CPR. Calculated bicarbonate and CO2 content (CCO2) did not increase during CPR from any site compared to control values and actually decreased significantly in arterial and myocardial venous samples. Changes in hydrogen ion concentration in both mixed venous and myocardial venous blood correlated with changes in lactate concentration but not total CCO2. Our results during CPR demonstrate a) a significant discrepancy between arterial and mixed venous blood gases but also a large and significant discrepancy between mixed venous and myocardial venous blood gases, b) significant anaerobic systemic and myocardial metabolism, and c) that mixed venous and myocardial venous acidosis is possibly a result of lactic acidosis.
E V Capparelli; M S Chow; J Kluger; A Fieldman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  17     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-07     Completed Date:  1989-06-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  442-6     Citation Subset:  AIM; IM    
Department of Pharmacy, Hartford Hospital, CT.
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MeSH Terms
Acid-Base Equilibrium*
Blood Gas Analysis
Heart Arrest / blood*
Lactates / blood
Myocardium / metabolism*
Reg. No./Substance:

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