| Differences in subcortical structures in young adolescents at familial risk for schizophrenia: A preliminary study. | |
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MedLine Citation:
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PMID: 23146250 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Schizophrenia has been associated with reduced volumes of subcortical structures on MRI, but the relation of these reductions to familial risk for the disorder is unclear. We investigated the effect of familial risk for schizophrenia on regional subcortical volumes during adolescence, a period marked by steep maturational changes in brain structure and the emergence of psychotic symptoms. A group of 26 non-help-seeking, first-degree relatives of patients with schizophrenia and 43 matched healthy comparisons, between 9 and 18 years of age, underwent MRI scanning and were rated for the presence of prodromal symptoms. Five subcortical regions-of-interest were tested for group differences and group by age interactions, as well as correlations with low-level prodromal symptoms in the familial risk group. Relative to comparisons, familial risk subjects demonstrated greater positive volume-age relationships in hippocampus, putamen, and globus pallidus. These results suggest that relatives of individuals with schizophrenia exhibit structural abnormalities in the subcortex as early as pre-adolescence, which may reflect altered neurodevelopment of these regions. |
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Authors:
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Michael K Dougherty; Hongbin Gu; Joshua Bizzell; Stacy Ramsey; Guido Gerig; Diana O Perkins; Aysenil Belger |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-9 |
Journal Detail:
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Title: Psychiatry research Volume: - ISSN: 1872-7123 ISO Abbreviation: Psychiatry Res Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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University of North Carolina School of Medicine, Department of Psychiatry, Chapel Hill, NC, United States. Electronic address: Michael_Dougherty@uphs.upenn.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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