Document Detail


Differences in subcortical structures in young adolescents at familial risk for schizophrenia: a preliminary study.
MedLine Citation:
PMID:  23146250     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Schizophrenia has been associated with reduced volumes of subcortical structures on magnetic resonance imaging (MRI), but the relation of these reductions to familial risk for the disorder is unclear. We investigated the effect of familial risk for schizophrenia on regional subcortical volumes during adolescence, a period marked by steep maturational changes in brain structure and the emergence of psychotic symptoms. A group of 26 non-help-seeking, first-degree relatives of patients with schizophrenia and 43 matched healthy comparisons, between 9 and 18 years of age, underwent MRI scanning and were rated for the presence of prodromal symptoms. Five subcortical regions-of-interest were tested for group differences and group by age interactions, as well as correlations with low-level prodromal symptoms in the familial risk group. Relative to comparisons, familial risk subjects demonstrated greater positive volume-age relationships in hippocampus, putamen, and globus pallidus. These results suggest that relatives of individuals with schizophrenia exhibit structural abnormalities in the subcortex as early as pre-adolescence, which may reflect altered neurodevelopment of these regions.
Authors:
Michael K Dougherty; Hongbin Gu; Joshua Bizzell; Stacy Ramsey; Guido Gerig; Diana O Perkins; Aysenil Belger
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-10
Journal Detail:
Title:  Psychiatry research     Volume:  204     ISSN:  1872-7123     ISO Abbreviation:  Psychiatry Res     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-30     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  68-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Age Factors
Analysis of Variance
Brain / growth & development*,  pathology*
Case-Control Studies
Child
Female
Functional Laterality
Humans
Image Processing, Computer-Assisted
Longitudinal Studies
Magnetic Resonance Imaging
Male
Risk Factors
Schizophrenia / pathology*
Statistics as Topic
Grant Support
ID/Acronym/Agency:
2-R01MH058251/MH/NIMH NIH HHS; MH064065/MH/NIMH NIH HHS; P50 MH064065/MH/NIMH NIH HHS; R01 MH058251/MH/NIMH NIH HHS; U54EB005149/EB/NIBIB NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Salience network-midbrain dysconnectivity and blunted reward signals in schizophrenia.
Next Document:  Structural brain features of borderline personality and bipolar disorders.