Document Detail

Differences in stroke outcome based on sex.
MedLine Citation:
PMID:  20194917     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Stroke thrombolysis may have a differential effect by sex. We sought to examine the relationship between sex and outcome after thrombolysis.
METHODS: This is a retrospective cohort study of stroke patients from the Registry of Canadian Stroke Network phase 1 (June 2001-February 2002) and phase 2 (June 2002-December 2002). Variables including demographics, history, clinical data, process measures, and outcome were analyzed. The primary outcomes were the Stroke Impact Scale-16 score (SIS-16) and mortality at 6 months. We compared the outcomes of the thrombolyzed and nonthrombolyzed cohorts and examined the data for a tissue plasminogen activator (tPA)-by-sex interaction on the 2 primary outcomes.
RESULTS: The overall proportion of patients who achieved an excellent outcome (SIS-16 >75) was not different by gender. However, the proportion of patients achieving an excellent outcome in the non-tPA cohort was much greater in males, with an absolute risk difference of 11.8%. A multiplicative treatment by sex interaction was evident (p = 0.054). This interaction was not present for stroke case fatality.
CONCLUSIONS: Women fared poorly compared to men in the placebo groups, but this negative prognostic sex effect was neutralized by thrombolysis.
N Shobha; P N Sylaja; M K Kapral; J Fang; M D Hill;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  74     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-02     Completed Date:  2010-04-06     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  767-71     Citation Subset:  AIM; IM    
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, T2N 2T9, Canada.
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MeSH Terms
Aged, 80 and over
Canada / epidemiology
Cohort Studies
Follow-Up Studies
Middle Aged
Retrospective Studies
Severity of Illness Index
Sex Factors
Stroke / epidemiology*,  mortality,  therapy
Thrombolytic Therapy
Time Factors
Tissue Plasminogen Activator / therapeutic use
Treatment Outcome
Reg. No./Substance:
EC Plasminogen Activator
Erratum In:
Neurology. 2010 Mar 23;74(12):1008

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