Document Detail

Differences in skeletal muscle between men and women with chronic heart failure.
MedLine Citation:
PMID:  11133920     Owner:  NLM     Status:  MEDLINE    
Men with chronic heart failure (CHF) have alterations in their skeletal muscle that are partially responsible for a decreased exercise tolerance. The purpose of this study was to investigate whether skeletal muscle alterations in women with CHF are similar to those observed in men and if these alterations are related to exercise intolerance. Twenty-five men and thirteen women with CHF performed a maximal exercise test for evaluation of peak oxygen consumption (VO(2)) and resting left ventricular ejection fraction, after which a biopsy of the vastus lateralis was performed. Twenty-one normal subjects (11 women, 10 men) were also studied. The relationship between muscle markers and peak VO(2) was consistent for CHF men and women. When controlling for gender, analysis showed that oxidative enzymes and capillary density are the best predictors of peak VO(2.) These results indicate that aerobically matched CHF men and women have no differences in skeletal muscle biochemistry and histology. However, when CHF groups were separated by peak exercise capacity of 4.5 metabolic equivalents (METs), CHF men with peak VO(2) >4.5 METs had increased citrate synthase and 3-hydroxyacyl-CoA dehydrogenase compared with CHF men with peak VO(2) <4.5 METs. CHF men with a lower peak VO(2) had increased capillary density compared with men with higher peak VO(2). These observations were not reproduced in CHF women. This suggests that differences may exist in how skeletal muscle adapts to decreasing peak VO(2) in patients with CHF.
B D Duscha; B H Annex; S J Keteyian; H J Green; M J Sullivan; G P Samsa; C A Brawner; F H Schachat; W E Kraus
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  90     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-16     Completed Date:  2001-03-29     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  280-6     Citation Subset:  IM    
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
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MeSH Terms
Capillaries / pathology
Cardiac Output, Low / metabolism*,  pathology*,  physiopathology
Chronic Disease
Citrate (si)-Synthase / metabolism
Enoyl-CoA Hydratase / metabolism
Exercise Test
Middle Aged
Muscle, Skeletal / blood supply,  enzymology,  metabolism*,  pathology*
Oxygen Consumption
Physical Endurance
Sex Characteristics*
Stroke Volume
Grant Support
Reg. No./Substance:
EC (si)-Synthase; EC Hydratase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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