Document Detail


Differences in the retinohypothalamic tract in albino Lewis versus brown Norway rat strains.
MedLine Citation:
PMID:  8390623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Differences in sleep-wake patterns in response to light-dark stimulation have been observed between albino Lewis and pigmented Brown Norway strains of rats, which may be associated with albinism. Since several anatomical differences have been demonstrated in the visual pathways of albino and pigmented mammals, the present study was undertaken to determine whether additional differences in visual pathways of these rat strains exist that might account for their behavioral differences. Using anterograde tracing techniques and image analysis, we have investigated the retinal projections of Lewis and Brown Norway rats. Our results demonstrate that the distribution of retinal terminals in the hypothalamic suprachiasmatic nucleus extends over a greater area in Lewis compared to Brown Norway rats. This zone of termination corresponds to a cytoarchitectonically definable ventrolateral subdivision of the suprachiasmatic nucleus (SCN), which is also greater in Lewis than in Brown Norway rats. These results may have implications for behaviors related to the SCN.
Authors:
T L Steininger; D B Rye; M A Gilliland; B H Wainer; R M Benca
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience     Volume:  54     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-20     Completed Date:  1993-07-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  11-4     Citation Subset:  IM    
Affiliation:
Committee on Neurobiology, University of Chicago, IL 60637.
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MeSH Terms
Descriptor/Qualifier:
Albinism / pathology*
Animals
Hypothalamus / pathology*
Pigmentation*
Rats / anatomy & histology*
Rats, Inbred Lew / anatomy & histology*
Retina / pathology*,  physiopathology
Suprachiasmatic Nucleus / pathology
Synaptic Transmission
Visual Pathways / pathology
Grant Support
ID/Acronym/Agency:
MH09919/MH/NIMH NIH HHS; NS17661/NS/NINDS NIH HHS; NS27730/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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