Document Detail


Differences in resting corticolimbic functional connectivity in bipolar I euthymia.
MedLine Citation:
PMID:  23347587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE:   We examined resting state functional connectivity in the brain between key emotion regulation regions in bipolar I disorder to delineate differences in coupling from healthy subjects.
METHODS:   Euthymic subjects with bipolar I disorder (n = 20) and matched healthy subjects (n = 20) participated in a resting state functional magnetic resonance imaging scan. Low-frequency fluctuations in blood oxygen level-dependent (BOLD) signal were correlated in the six connections between four anatomically defined nodes: left and right amygdala and left and right ventrolateral prefrontal cortex (vlPFC). Seed-to-voxel connectivity results were probed for commonly coupled regions. Following this, an identified region was included in a mediation analysis to determine the potential of mediation.
RESULTS:   The bipolar I disorder group exhibited significant hyperconnectivity between right amygdala and right vlPFC relative to healthy subjects. The connectivity between these regions in the bipolar I disorder group was partially mediated by activity in the anterior cingulate cortex (ACC).
CONCLUSIONS:   Greater coupling between right amygdala and right vlPFC and their partial mediation by the ACC were found in bipolar I disorder subjects in remission and in the absence of a psychological task. These findings have implications for a trait-related and clinically important imaging biomarker.
Authors:
Salvatore Torrisi; Teena D Moody; Nathalie Vizueta; Moriah E Thomason; Martin M Monti; Jennifer D Townsend; Susan Y Bookheimer; Lori L Altshuler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-24
Journal Detail:
Title:  Bipolar disorders     Volume:  15     ISSN:  1399-5618     ISO Abbreviation:  Bipolar Disord     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-29     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  100883596     Medline TA:  Bipolar Disord     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  156-66     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bipolar Disorder / pathology*
Case-Control Studies
Cerebral Cortex / blood supply,  physiopathology*
Female
Functional Laterality
Humans
Image Processing, Computer-Assisted
Limbic System / blood supply,  physiopathology*
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways / blood supply,  physiopathology*
Oxygen / blood
Rest*
Grant Support
ID/Acronym/Agency:
K24 MH001848/MH/NIMH NIH HHS; K24 MH001848/MH/NIMH NIH HHS; R01 MH084955/MH/NIMH NIH HHS; R01 MH084955/MH/NIMH NIH HHS; R21 MH075944/MH/NIMH NIH HHS; R21 MH075944/MH/NIMH NIH HHS; RR00865/RR/NCRR NIH HHS; RR12169/RR/NCRR NIH HHS; RR13642/RR/NCRR NIH HHS; T32 MH017140/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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