Document Detail


Differences in perinatal transmission among human immunodeficiency virus type 1 genotypes.
MedLine Citation:
PMID:  11213929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether genotypes from human immunodeficiency virus type 1 (HIV-1) subtypes A, C, or D or intersubtype recombinants have the same probability of being transmitted from mother to child. METHODS: We determined the HIV-1 genetic subtype and maternal risk factors of 51 matched transmitting and nontransmitting mothers from Tanzania. The HIV-1 gag (p24-p7) and env (C2-C5) nucleotide sequences were used for genotype classification, and matched logistic regression analysis was used to assess differences among genotypes. RESULTS: Mothers infected with HIV-1 subtype A (odds ratio, 3.8; 95% CI, 0.8-24.7%), HIV-1 subtype C (odds ratio, 5.1; 95% CI, 1.3-30.8%), or HIV-1 intersubtype recombinant viruses (odds ratio, 5.3; 95% CI, 1.2-33.4%) were more likely to transmit HIV-1 to their infants than mothers infected with HIV-1 subtype D. Lower CD4 cell counts at enrollment were associated with transmission, but CD4 cell counts within each genotype did not explain differences in transmission among HIV-1 genotypes. CONCLUSION: We have shown that HIV-1 genotypes might be associated with differential risk for vertical transmission. These findings provide the first evidence that HIV-1 genetic subtypes may play a role in rates of vertical transmission in an African setting.
Authors:
B Renjifo; W Fawzi; D Mwakagile; D Hunter; G Msamanga; D Spiegelman; M Garland; C Kagoma; A Kim; B Chaplin; E Hertzmark; M Essex
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of human virology     Volume:  4     ISSN:  1090-9508     ISO Abbreviation:  J. Hum. Virol.     Publication Date:    2001 Jan-Feb
Date Detail:
Created Date:  2001-02-13     Completed Date:  2001-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9805755     Medline TA:  J Hum Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-25     Citation Subset:  IM    
Affiliation:
Department of Immunology & Infectious Diseases, Harvard Medical School of Public Health, Boston, Massachusetts 02115-6017, USA. brenjifo@hsph.harvard.edu
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF283108;  AF283109;  AF283110;  AF283111;  AF283112;  AF283113;  AF283114;  AF283115;  AF283116;  AF283117;  AF283118;  AF283119;  AF283120;  AF283121;  AF283122;  AF283123;  AF283124;  AF283125;  AF283126;  AF283127;  AF283128;  AF283129;  AF283130;  AF283131;  AF283132;  AF283133;  AF283134;  AF283135;  AF283136;  AF283137
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Capsid / genetics
Capsid Proteins*
Case-Control Studies
DNA, Viral
Double-Blind Method
Female
Gene Products, env / genetics
Gene Products, gag / genetics
Genotype
HIV Core Protein p24 / genetics
HIV Infections / blood,  transmission,  virology*
HIV-1 / classification,  genetics*
Humans
Infant
Infant, Newborn
Molecular Sequence Data
Risk Factors
Viral Proteins*
gag Gene Products, Human Immunodeficiency Virus
Grant Support
ID/Acronym/Agency:
R01 HD32257/HD/NICHD NIH HHS; R01 HD37783/HD/NICHD NIH HHS; R35 CA39805/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Capsid Proteins; 0/DNA, Viral; 0/Gene Products, env; 0/Gene Products, gag; 0/HIV Core Protein p24; 0/NCP7 protein, Human immunodeficiency virus 1; 0/Viral Proteins; 0/gag Gene Products, Human Immunodeficiency Virus

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