| Differences in overshoot of blood pressure after head-up tilt in two groups with chronic autonomic failure: pure autonomic failure and multiple system atrophy. | |
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MedLine Citation:
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PMID: 15654557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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On head down tilt to the supine horizontal position (tilt reversal) after head up tilt (HUT), patients with orthostatic hypotension may show an increase in blood pressure (BP) relative to baseline readings. We assessed this BP overshoot in 8 patients with pure autonomic failure (PAF, 64+/-13 years) and 8 patients with multiple system atrophy (MSA, 66+/-10 years). BP was intermittently measured during pre-tilt supine, HUT (60 degrees , 10 min), and post-tilt supine periods. In addition, beat-to-beat BP was measured continuously using the Portapres model 2 device to calculate stroke volume (SV), cardiac output (CO) and total peripheral resistance (TPR). There was systolic BP overshoot of > or = 15 mmHg after tilt reversal in 5 out of 8 PAF, but in only one of 8 MSA. A mean increase of systolic BP in PAF was significantly higher than that in MSA (p<0.01). TPR increased over baseline level after tilt reversal, although there was no significant difference. SV and CO levels during the post-tilt supine period were similar to baseline levels. In conclusion, BP overshoot was prominent in the PAF group but not in the MSA group. The phenomenon of BP overshoot while supine, especially in PAF, may have implications for long term cardiac and vascular damage in such patients. |
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Authors:
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Masato Asahina; Tim M Young; Katharine Bleasdale-Barr; Christopher J Mathias |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurology Volume: 252 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-17 Completed Date: 2005-04-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 72-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan. asahina@faculty.chiba-u.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Autonomic Nervous System / physiopathology Autonomic Nervous System Diseases / diagnosis, physiopathology* Blood Pressure / physiology Cardiac Output / physiology Female Humans Hypertension / diagnosis, etiology*, physiopathology* Male Middle Aged Multiple System Atrophy / diagnosis, physiopathology* Posture / physiology Stroke Volume / physiology Tilt-Table Test |
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