Document Detail

Differences in outcome between twins and singletons born very preterm: results from a population-based European cohort.
MedLine Citation:
PMID:  20118116     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: About 10% of twins are born before 32 weeks of gestation and very preterm birth rates are increasing. Preterm twins tend to have more favourable outcomes than singletons of the same gestational age, but fewer data are available for very preterm infants. This study aims to determine whether outcomes differ between very preterm twins and singletons.
METHOD: This study was of a population-based cohort of very preterm babies in 10 European regions in 2003. Mortality and morbidity to discharge from hospital were compared for twins and singletons between 24 and 31 weeks of gestation, who were alive at the onset of labour and without lethal congenital anomalies. Clinical characteristics, pregnancy complications and healthcare factors were taken into consideration.
RESULTS: Between 28 and 31 weeks of gestation, mortality and oxygen dependency at 36 corrected weeks of gestation were lower for twins than singletons (3.9 versus 6.5% and 7.1 versus 10.4%, respectively), but this advantage disappeared after controlling for medical and healthcare factors. Hypertension, growth restriction and haemorrhaging were less frequent complications of twin birth and more twins received antenatal corticosteroids and were born in level III units. In contrast, between 24 and 27 weeks of gestation, twins had higher adjusted risks of mortality and Grade III/IV intraventricular haemorrhaging [adjusted ORs 1.5 (95% CI 1.1-2.2) and 1.5 (1.0-2.1)]. These adverse outcomes were concentrated among twins from same sex pairs with discordant birthweights.
CONCLUSIONS: Between 24 and 27 weeks of gestation, risks of mortality and severe cranial haemorrhaging were higher for twins than singletons if they were from same sex pairs with discordant birthweights.
Emile Papiernik; Jennifer Zeitlin; Dominique Delmas; Béatrice Blondel; Wolfgang Künzel; Marina Cuttini; Tom Weber; Stavros Petrou; Ludwig Gortner; Louis Kollée; Elizabeth S Draper;
Related Documents :
8883756 - Antepartum and postpartum complications of twin-twin transfusion.
446786 - Gestational outcome of clomiphene-related conceptions.
8572036 - Perinatal mortality in twins and singletons matched for gestational age at delivery at ...
9548186 - Ovine placentome morphology: effect of high altitude, long-term hypoxia.
3939146 - Cost-effectiveness of immunization in the gambia.
16892856 - An investigation of the factors influencing the choice of infant feeding methods among ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Twin Study     Date:  2010-01-29
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  25     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-17     Completed Date:  2010-06-17     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1035-43     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cohort Studies
Europe / epidemiology
Gestational Age
Infant Mortality*
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / epidemiology,  mortality
Pregnancy Outcome
Prospective Studies
Risk Factors
Young Adult
Grant Support
G0501681//Medical Research Council
E Martens / ; G Martens / ; P Van Reempts / ; K Boerch / ; T Weber / ; B Peitersen / ; G Bréart / ; J L Chabernaud / ; D Delmas / ; P H Jarreau / ; E Papiernik / ; L Gortner / ; W Künzel / ; R F Maier / ; B Misselwitz / ; S Schmidt / ; R Agostino / ; D Di Lallo / ; R Paesano / ; L den Ouden / ; L Kollée / ; G Visser / ; J Gerrits / ; R de Heus / ; G Breborowicz / ; J Gadzinowski / ; J Mazela / ; H Barros / ; I Campos / ; M Carrapato / ; E Draper / ; D Field / ; J Konje / ; A Fenton / ; D Milligan / ; S Sturgiss / ; B Blondel / ; H Pilkington / ; J Zeitlin /
Erratum In:
Hum Reprod. 2010 Sep;25(9):2404

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimen...
Next Document:  A fast and automated solution for accurately resolving protein domain architectures.