Document Detail

Differences in the membrane skeleton proteins of RBC of AMoL patients.
MedLine Citation:
PMID:  2487359     Owner:  NLM     Status:  MEDLINE    
We report here the different components of erythrocyte membrane skeleton proteins between acute monocytic leukemic (AMoL) patients and normal people. The bands in the 2 region of ghost membrane from AMoL patients exhibited significant differences on SDS gel electrophoresis. Band 2.2 was found to be missing and a "new" band with molecular weight (MW) 161,000 appeared. Also band 4.9 was missing, and the amounts of spectrin, actin, and band 4.8 of AMoL patients were decreased markedly. No such alterations can be seen in normal individuals, even in acute myeloid leukemic (AML) and chronic myeloid leukemic (CML) patients.
B N Cao; J H Wang; B A Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Membrane biochemistry     Volume:  8     ISSN:  0149-046X     ISO Abbreviation:  Membr Biochem     Publication Date:  1989  
Date Detail:
Created Date:  1991-03-14     Completed Date:  1991-03-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7804153     Medline TA:  Membr Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  241-6     Citation Subset:  IM    
Department of Biochemistry, Harbin Medical University, Hei Longjiang, China.
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MeSH Terms
Actins / blood,  deficiency
Blood Proteins / deficiency
Electrophoresis, Polyacrylamide Gel
Erythrocyte Membrane / chemistry*
Leukemia, Monocytic, Acute / blood*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood
Leukemia, Myeloid, Acute / blood
Membrane Proteins / blood*,  deficiency
Molecular Weight
Spectrin / deficiency
Reg. No./Substance:
0/Actins; 0/Blood Proteins; 0/EPB49 protein, human; 0/Membrane Proteins; 0/Phosphoproteins; 12634-43-4/Spectrin

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