| Differences in the mechanisms of the thermoregulatory impairment induced by capsaicin in newborn and adult rats. | |
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MedLine Citation:
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PMID: 3661220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The function of heat defence was compared in rats pretreated as adults (A-rats) and neonates (N-rats) with capsaicin. The thermoregulatory impairment as tested by whole body heating was similar in A-rats and N-rats. The thermosensitivity and chemosensitivity of the preoptic region (RPO) seemed to be normal in N-rats. A deficiency of RPO mechanisms could be demonstrated in A-rats. It is suggested that the preoptic effects of capsaicin have but a minor significance for the thermoregulatory impairment. It seems that the main cause of decreased heat tolerance is a reduction of peripheral warm sensation due to degeneration of unmyelinated C-fibre primary neurons in both A-rats and N-rats. The results do not support the primary importance of preoptic warm sensation in physiological thermoregulation. |
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Authors:
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F Obál; G Jancsó; M Hajós; F Obál |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta physiologica Hungarica Volume: 69 ISSN: 0231-424X ISO Abbreviation: Acta Physiol Hung Publication Date: 1987 |
Date Detail:
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Created Date: 1987-11-19 Completed Date: 1987-11-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309201 Medline TA: Acta Physiol Hung Country: HUNGARY |
Other Details:
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Languages: eng Pagination: 437-45 Citation Subset: IM |
Affiliation:
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Department of Physiology, University Medical School, Szeged, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Body Temperature Regulation / drug effects* Capsaicin / pharmacology* Nerve Degeneration / drug effects Preoptic Area / drug effects, physiology Rats Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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