| Differences in locomotor performance between individuals: importance of parvalbumin, calcium handling and metabolism. | |
| | |
MedLine Citation:
|
PMID: 22279074 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Locomotor performance is linked to fitness and health of animals and is expected to be under strong selection. However, interindividual variation in locomotor performance is pronounced in many species. It was our aim to investigate the relative importance of energy metabolism and calcium handling in determining sprint and sustained locomotion in the zebrafish (Danio rerio). Sprint and sustained performance (U(crit)) varied independently from each other. Using in vivo electroporation, we found that increased parvalbumin protein concentration improved both sprint and sustained locomotion. This is the first demonstration that parvalbumin plays a role in determining whole-animal performance. High sprint performance fish had greater mRNA concentrations of the metabolic regulators PPARδ and PGC1β compared with fish with poor sprint performance. High sustained performance fish, in contrast, had greater concentrations of PGC-1α and PGC-1β. The increased expression of these metabolic regulators indicates an enhancement of the metabolic machinery in high performance animals. Sprint performance is also enhanced by creatine kinase activity, which may be associated with increased PPARδ mRNA concentration. Ryanodine receptor (RyR) and sarcoplasmic reticulum Ca(2+)-ATPase 1 (SERCA1) mRNA concentrations were significantly increased in high sustained performance fish, while parvalbumin 2, dihydropyridine (DHPR) receptor and SERCA2 mRNA levels were increased in fish with high sprint velocities. Sustained performance was more sensitive to experimentally induced decreases in RyR and DHPR activity than sprint performance. We provide mechanistic explanations of why locomotor performance differs between individuals, which is important for understanding ecological and sporting success, disease and the evolutionary processes underlying selection. |
| | |
Authors:
|
Frank Seebacher; Isabel Walter |
Related Documents
:
|
15572034 - Transforming growth factor-beta inhibits ccaat/enhancer-binding protein expression and ... 19876584 - Biphasic glucocorticoid-dependent regulation of wnt expression and its inhibitors in ma... 20820764 - The expression of il-6 by osteoblasts is increased in healthy elderly individuals: stim... 9298364 - Expression of bmp-2 and tgf-beta 1 mrna during healing of the rabbit mandible. 18941244 - Differential regulation of chemokines by il-17 in colonic epithelial cells. 10718114 - Regulation of icam-1 expression in mouse macrophages. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of experimental biology Volume: 215 ISSN: 1477-9145 ISO Abbreviation: J. Exp. Biol. Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0243705 Medline TA: J Exp Biol Country: England |
Other Details:
|
Languages: eng Pagination: 663-70 Citation Subset: IM |
Affiliation:
|
School of Biological Sciences A08, University of Sydney, NSW 2006, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glass scales on the wing of the swordtail butterfly Graphium sarpedon act as thin film polarizing re...
Next Document: Hydrodynamics of the bluegill sunfish C-start escape response: three-dimensional simulations and com...