Document Detail

Differences in inhaled fluticasone bioavailability between holding chambers in children with asthma.
MedLine Citation:
PMID:  12173797     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To determine if differences between holding chambers in previous in vitro aerosol studies would agree with the bioavailability of inhaled fluticasone propionate between the same holding chambers in children with asthma. DESIGN: Double-blind, randomized, crossover study SETTING: University of Florida Clinical Research Center. PATIENTS: Eight children (aged 5-9 yrs) with stable asthma. INTERVENTION: Under observation, the children inhaled two 110-microg puffs of fluticasone twice/day through the InspirEase or E-Z Spacer holding chamber. MEASUREMENTS AND MAIN RESULTS: Blood samples were collected at baseline and then at 0.5, 1, 1.5, 2, 4, and 6 hours after the last dose of fluticasone. Primary outcome measures were peak fluticasone steady-state plasma concentration (Cmax) and area under the fluticasone plasma concentration-time curve from 0-6 hours (AUC0-6). The fluticasone plasma concentrations were determined by high-performance liquid chromatography-mass spectrometric assay. Mean +/- SD Cmax from InspirEase (245 +/- 77 pg/ml) was 18% higher than that after E-Z Spacer (199 +/- 58 pg/ml, p < 0.05). Mean +/- SD AUC0-6 from InspirEase (1103 +/- 305 pg x hr(-1) x ml(-1) was 22% higher than that delivered from E-Z Spacer (863 +/- 258 pg x hr(-1) x ml(-1), p = 0.06). CONCLUSION: Differences in inhaled fluticasone bioavailability between these holding chambers in children with asthma corroborate differences reported in earlier in vitro aerosol studies.
Judy Liang; Michael J Asmus; Günther Hochhaus; Sarah Chesrown; Leslie Hendeles
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacotherapy     Volume:  22     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-13     Completed Date:  2003-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  947-53     Citation Subset:  IM    
Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville 32610-0486, USA.
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MeSH Terms
Administration, Inhalation
Androstadienes / administration & dosage,  blood*
Area Under Curve
Asthma / blood*
Biological Availability
Bronchodilator Agents / administration & dosage,  blood*
Child, Preschool
Cross-Over Studies
Double-Blind Method
Nebulizers and Vaporizers*
Reg. No./Substance:
0/Aerosols; 0/Androstadienes; 0/Bronchodilator Agents; 90566-53-3/fluticasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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