Document Detail

Differences in impaired brainstem conduction between neonatal chronic lung disease and perinatal asphyxia.
MedLine Citation:
PMID:  20097607     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To explore any differences in impaired brainstem function between preterm infants with neonatal chronic lung disease (CLD) and term infants after perinatal asphyxia. METHODS: Brainstem auditory evoked responses (BAERs) collected using maximum length sequence (MLS) technique were compared at term equivalent age between 43 CLD infants and 117 asphyxiated infants. RESULTS: In both CLD and asphyxiated infants there was a significant increase in wave V latency and I-V interval in MLS BAER. CLD infants showed a significant increased III-V interval but a normal I-III interval at all click rates. However, asphyxiated infants showed a significant increase in both III-V and I-III intervals. I-III interval was shorter and III-V/I-III interval ratio was greater in CLD infants than in asphyxiated infants. The slope of I-III interval-rate function was steeper in asphyxiated infants than in CLD infants, while the slope of III-V/I-III interval ratio-rate function was the other way around. CONCLUSIONS: CLD infants had a major increase in more central components of MLS BAER, without appreciable abnormality in more peripheral components. However, asphyxiated infants had a significant increase in both central and peripheral components. SIGNIFICANCE: Neonatal CLD affects more central regions of the brainstem, whereas perinatal asphyxia affects both peripheral and central regions. This difference, which is likely related to the different nature of hypoxia in CLD and asphyxia, may have some significance for neuroprotective interventions for the two problems.
Ze D Jiang; Dorothea M Brosi; Andrew R Wilkinson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-25
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  121     ISSN:  1872-8952     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-03-30     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  725-33     Citation Subset:  IM    
Copyright Information:
Copyright 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Children's Hospital, Shanghai Medical University, Shanghai, China.
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MeSH Terms
Asphyxia Neonatorum / physiopathology*
Brain Stem / physiopathology*
Chronic Disease
Evoked Potentials, Auditory, Brain Stem
Infant, Newborn
Infant, Premature*
Lung Diseases / physiopathology*
Neural Conduction*
Reaction Time
Term Birth*
Grant Support
//Wellcome Trust

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