| Differences in hemodynamic effects of nitroprusside and prazosin in severe chronic congestive heart failure: evidence for a direct negative chronotropic effect of prazosin. | |
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MedLine Citation:
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PMID: 463769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To compare the hemodynamic effects of prazosin and nitroprusside in patients with severe congestive heart failure, nine patients with heart failure refractory to conventional therapy received oral prazosin and intravenous nitroprusside administered so as to produce a similar decrease in left ventricular filling pressure in each patient. By this comparison, both drugs produced similar decreases in mean right atrial pressure, mean pulmonary arterial pressure and systemic and pulmonary vascular resistance. However, with nitroprusside, cardiac index increased more (+0.97 versus +0.73 liters/min per m2, P less than 0.01) and mean arterial pressure decreased less (-13.7 versus -18.3 mm Hg, P less than 0.05) than with prazosin. Both drugs produced similar changes in stroke volume index (+11.7 cc/beat per m2 with nitroprusside and +12.5 with prazosin) and stroke work index (+8.1 g-m/m2 with nitroprusside and +6.6 with prazosin). Therefore, the differences in the hemodynamic responses observed with the two agents were due to the significantly greater decrease in heart rate with prazosin (-8 beats/min) than with nitroprusside (-2 beats/min, P less than 0.05). These clinical data support experimental evidence suggesting that there is a significant negative chronotropic action of prazosin independent of its peripheral vascular effects. |
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Authors:
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M Packer; J Meller; R Gorlin; M V Herman |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 44 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1979 Aug |
Date Detail:
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Created Date: 1979-09-25 Completed Date: 1979-09-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 310-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aged Female Ferricyanides / pharmacology* Heart Failure / drug therapy*, physiopathology Heart Rate / drug effects* Hemodynamics / drug effects* Humans Infusions, Parenteral Male Middle Aged Nitroprusside / pharmacology* Prazosin / pharmacology* Quinazolines / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Ferricyanides; 0/Quinazolines; 15078-28-1/Nitroprusside; 19216-56-9/Prazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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