| Differences in glucose tolerance between deficit and nondeficit schizophrenia. | |
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MedLine Citation:
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PMID: 19046857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Some studies suggest that schizophrenia is associated with an increased risk of diabetes independently of antipsychotic use. People with deficit schizophrenia, which is characterized by primary (or idiopathic), enduring negative symptoms, differ from those with nondeficit schizophrenia on course of illness, treatment response, risk factors, and biological correlates. We hypothesized that deficit and nondeficit subjects would also differ with regard to glucose tolerance. Newly diagnosed, antipsychotic-naïve subjects with nonaffective psychosis and matched control subjects were administered a 75 g oral glucose tolerance test (GTT). Two-hour glucose concentrations were significantly higher in the nondeficit patients (N=23; mean [SD] of 121.6 [42.0]) than in deficit (N=23; 100.2 [23.1]) and control subjects (N=59; 83.8 [21.9]); the deficit subjects also had significantly higher two-hour glucose concentrations than did the control subjects. These results provide further support that the deficit group has a distinctive etiopathophysiology. |
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Authors:
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Brian Kirkpatrick; Emilio Fernandez-Egea; Clemente Garcia-Rizo; Miguel Bernardo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-11-28 |
Journal Detail:
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Title: Schizophrenia research Volume: 107 ISSN: 0920-9964 ISO Abbreviation: Schizophr. Res. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-23 Completed Date: 2009-04-20 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 122-7 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia 30912, USA. bkirkpatrick2@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affective Symptoms / blood*, diagnosis, genetics, psychology Body Mass Index Case-Control Studies Diabetes Mellitus, Type 2 / blood, diagnosis, genetics, psychology Female Genetic Predisposition to Disease / genetics Glucose Tolerance Test* Humans Male Psychiatric Status Rating Scales Risk Factors Schizophrenia / blood*, diagnosis, genetics Schizophrenic Psychology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK069265/DK/NIDDK NIH HHS; R01 DK069265-04/DK/NIDDK NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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