| Differences in germinal centre and non-germinal center phenotype in gastric and intestinal diffuse large B-cell lymphomas. | |
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MedLine Citation:
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PMID: 18798105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gastrointestinal tract is the most common extranodal site of lymphoma, and the most common gastrointestinal lymphoma is diffuse large B-cell type (DLBCL). DLBCL can be separated into germinal centre (GCP) and non-germinal centre phenotypes (non-GCP) using CD10, BCL-6 and MUM1 immunohistochemistry, but primary gastrointestinal DLBCL has not been extensively studied. We investigated 48 cases of primary gastrointestinal DLBCL (33% involving the small intestine, 50% the stomach, 13% the large intestine and 4% the ileocecal junction) and found that most (88%) DLBCL in the intestines were of GCP, while only 58% of gastric DLBCL were of GCP. This difference in GCP and non-GCP in gastric vs. intestinal DLBCL may be due to variations in lymphomagenesis reflecting acquired vs. native mucosa-associated lymphoid tissue. There was no significant difference in either overall survival or disease-free survival between the germinal centre and non-germinal centre groups. The distribution of Helicobacter pylori in different gastric DLBCL phenotypes raises interesting questions about the pathogenesis of H. pylori-associated lymphomas. |
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Authors:
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Kisha A Mitchell; William G Finn; Scott R Owens |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 49 ISSN: 1029-2403 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-17 Completed Date: 2008-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: England |
Other Details:
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Languages: eng Pagination: 1717-23 Citation Subset: IM |
Affiliation:
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Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Disease-Free Survival Female Germinal Center / pathology* Helicobacter pylori Humans Intestinal Neoplasms / mortality, pathology* Lymphoma, Large B-Cell, Diffuse / mortality, pathology* Male Middle Aged Phenotype Stomach Neoplasms / mortality, pathology* Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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