Document Detail


Differences in the functional neuroanatomy of inhibitory control across the adult life span.
MedLine Citation:
PMID:  11931287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inhibitory control, the ability to suppress irrelevant or interfering stimuli, is a fundamental cognitive function that deteriorates during aging, but little is understood about the bases of decline. Thus, we used event-related functional magnetic resonance imaging (fMRI) to study inhibitory control in healthy adults aged 18 to 78. Activation during "successful inhibition" occurred predominantly in right prefrontal and parietal regions and was more extensive, bilaterally and prefrontally, in the older groups. Presupplementary motor area was also more active in poorer inhibitory performers. Therefore, older adults activate areas that are comparable to those activated by young adults during inhibition, as well as additional regions. The results are consistent with a compensatory interpretation and extend the aging neuroimaging literature into the cognitive domain of inhibition.
Authors:
Kristy A Nielson; Scott A Langenecker; Hugh Garavan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychology and aging     Volume:  17     ISSN:  0882-7974     ISO Abbreviation:  Psychol Aging     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-04-04     Completed Date:  2002-10-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904079     Medline TA:  Psychol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  56-71     Citation Subset:  IM    
Affiliation:
Department of Psychology and the Integrative Neuroscience Research Center, Marquette University and Medical College of Wisconsin, Milwaukee 53201, USA. kristy.nielson@marquette.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aging / physiology*
Attention / physiology*
Brain Mapping
Cerebral Cortex / physiology*
Dominance, Cerebral / physiology
Female
Humans
Magnetic Resonance Imaging*
Male
Middle Aged
Neural Inhibition / physiology*
Parietal Lobe / physiology
Pattern Recognition, Visual / physiology*
Prefrontal Cortex / physiology
Psychomotor Performance / physiology*
Reaction Time / physiology*
Reference Values

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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