Document Detail

Differences in extinction responding and reinstatement of methamphetamine-seeking behavior between Fischer 344 and Lewis rats.
MedLine Citation:
PMID:  16574207     Owner:  NLM     Status:  MEDLINE    
Fischer 344 (F344) and Lewis (LEW) rats differ in a number of self-administration behaviors. Whether or not these strains differ in methamphetamine-primed reinstatement of extinguished responding is unknown. F344 and LEW rats were trained to self-administer intravenous (i.v.) methamphetamine (0.06 mg/kg) during daily 2-h limited access sessions for 14 days. Following methamphetamine self-administration, subjects underwent a minimum of 6 extinction sessions where responding on the previously active lever resulted in no programmed consequences. Following extinction sessions, we evaluated strain and dose dependency of methamphetamine-primed (0.06, 0.12, or 0.24 mg/kg/i.v.) reinstatement of responding. All subjects received each dose once. Dosing order was determined by utilizing a within-subjects Latin square design. We found partial strain differences in daily methamphetamine self-administration. In addition, F344 rats responded significantly more during the first extinction session compared LEW rats. Last, the LEW rats demonstrated a heightened propensity to reinstate responding following methamphetamine priming injections compared to F344 rats. Our results suggest that genetic background influences differences in methamphetamine-seeking behaviors in rats.
Paul J Kruzich; Jinlei Xi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-06
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  83     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-05-25     Completed Date:  2006-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-5     Citation Subset:  IM    
Department of Physiology, CA 2098, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA.
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MeSH Terms
Central Nervous System Stimulants / administration & dosage*
Disease Models, Animal
Extinction, Psychological / physiology*
Methamphetamine / administration & dosage*
Rats, Inbred F344
Rats, Inbred Lew
Self Administration
Species Specificity
Substance-Related Disorders / psychology*
Reg. No./Substance:
0/Central Nervous System Stimulants; 537-46-2/Methamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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