Document Detail

Differences in exposure assignment between conception and delivery: the impact of maternal mobility.
MedLine Citation:
PMID:  20415777     Owner:  NLM     Status:  MEDLINE    
In studies of reproductive outcomes, maternal residence at delivery is often the only information available to characterise environmental exposures during pregnancy. The goal of this investigation was to describe residential mobility during pregnancy and to assess the extent to which change of residence may result in exposure misclassification when exposure is based on the address at delivery. Maternal residential mobility was compared between neural tube defect cases and unaffected controls from Texas participants in the National Birth Defects Prevention Study (NBDPS). Maternal residential information was obtained from the NBDPS interview. Data from the U.S. EPA National Air Toxics Assessment [Assessment System for Population Exposure Nationwide (ASPEN)], modelled at the census tract level, were used to estimate benzene exposure based on address at conception and address at delivery. Quartiles of exposure were assigned based on these estimates and the quartile assignments based on address at conception and address at delivery were compared using traditional methods (kappa statistics) and a novel application of mixed-effects ordinal logistic regression. Overall, 30% of case mothers and 24% of control mothers moved during pregnancy. Differences in maternal residential mobility were not significant between cases and controls, other than case mothers who moved did so earlier during pregnancy than control mothers (P = 0.01). There was good agreement between quartiles of estimated benzene exposure at both addresses (kappa = 0.78, P < 0.0001). Based on the mixed-effects regression model, address at delivery was not significantly different from using address at conception when assigning quartile of benzene exposure based on estimates from ASPEN (odds ratio 1.03, 95% confidence interval 0.85, 1.25). Our results indicate that, in this Texas population, maternal residential movement is generally within short distances, is typically not different between cases and controls, and does not significantly influence benzene exposure assessment.
Philip J Lupo; Elaine Symanski; Wenyaw Chan; Laura E Mitchell; D Kim Waller; Mark A Canfield; Peter H Langlois
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  24     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  200-8     Citation Subset:  IM    
Division of Epidemiology and Disease Control, University of Texas School of Public Health, 1200 Herman Pressler Drive, Houston, TX 77030, USA.
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MeSH Terms
Air Pollutants / analysis,  toxicity*
Air Pollution / adverse effects,  analysis*
Benzene / analysis,  toxicity
Environmental Exposure / adverse effects*,  analysis
Maternal Exposure / adverse effects
Neural Tube Defects / epidemiology*,  etiology
Residential Mobility*
Young Adult
Reg. No./Substance:
0/Air Pollutants; 71-43-2/Benzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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