| Differences in the evolution of imipenem susceptibility among Klebsiella pneumoniae and Escherichia coli isolates during a 6-year period in a tertiary care hospital. | |
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MedLine Citation:
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PMID: 17207610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The evolution of imipenem disk-diffusion susceptibility results of 2652 strains of Klebsiella pneumoniae and 7596 Escherichia coli isolated during the period 2000-2005 were analysed. Screening for production of metallo-beta-lactamases was performed using the EDTA-synergy method. The percentage rate of K. pneumoniae isolates having a zone diameter < or =25 mm increased from 20% in 2000 to 41% in 2005, whereas the respective rate of isolates having a zone diameter > or =30 mm decreased from 48 to 23%. These changes were more evident during 2000-2002, followed in 2003 by the isolation of the first imipenem-resistant strains. Regarding E. coli, a similar decrease was observed (the rates of isolates having a zone diameter < or =25 mm and > or =30 mm changed from 7% and 68% in 2000, to 32% and 36% in 2005, respectively) following the respective changes of K. pneumoniae. A total of 20 K. pneumoniae strains, but no E. coli, were confirmed as metallo-beta-lactamase producers. In conclusion, a decrease of the imipenem susceptibility prior to the isolation of the first resistant strains in a tertiary care hospital was detected, as well as differences in this decrease between the two species. These findings indicate that monitoring of the evolution of imipenem susceptibility in real-time may help in unveiling forthcoming resistance and in implementing the appropriate diagnostic techniques. |
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Authors:
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Joseph Papaparaskevas; Angeliki Pantazatou; Ioanna Stefanou; Victoria Mela; Nikolaos Galatidis; Athina Avlamis |
Publication Detail:
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Type: Journal Article Date: 2007-01-04 |
Journal Detail:
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Title: International journal of antimicrobial agents Volume: 29 ISSN: 0924-8579 ISO Abbreviation: Int. J. Antimicrob. Agents Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-15 Completed Date: 2007-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111860 Medline TA: Int J Antimicrob Agents Country: Netherlands |
Other Details:
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Languages: eng Pagination: 197-200 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Laikon General Hospital, 11527 Athens, Greece. ipapapar@med.uoa.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology* Edetic Acid / pharmacology Escherichia coli / drug effects* Humans Imipenem / pharmacology* Klebsiella pneumoniae / drug effects* Microbial Sensitivity Tests beta-Lactamases / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 60-00-4/Edetic Acid; 74431-23-5/Imipenem; EC 3.5.2.6/beta-Lactamases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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