Document Detail

Differences in the consequences of the decay of radioactive 64Cu atoms incorporated in cells under either in vitro or in vivo conditions.
MedLine Citation:
PMID:  3615806     Owner:  NLM     Status:  MEDLINE    
To study the lethal effect of 64Cu under in vitro conditions, asynchronous mammalian cells were used. A lethal effect does exist as a consequence of the decay itself of a few 64Cu atoms incorporated in cellular DNA. This lethal effect is characterized by an exponential survival curve with no shoulder and no tail; it exists even for non-dividing cells. The lethal efficiency per decay is very high. To test the 64Cu lethal effect under in vivo conditions, experiments were performed with ascitic cells developing in mice. In this case, the lethal effect also exists, but it is not a function of the 64Cu doses injected in the mice. Faced with this puzzling result, a systemic approach was necessary to understand and counteract ascitic cells developing in mice.
S Apelgot; E Guillé
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Radiation and environmental biophysics     Volume:  26     ISSN:  0301-634X     ISO Abbreviation:  Radiat Environ Biophys     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-11     Completed Date:  1987-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0415677     Medline TA:  Radiat Environ Biophys     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  115-23     Citation Subset:  IM    
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MeSH Terms
Ascitic Fluid / pathology
Cell Line
Cell Survival / radiation effects
Cells, Cultured
Copper / metabolism,  therapeutic use*
DNA Damage
DNA, Neoplasm / radiation effects
Dose-Response Relationship, Radiation
Neoplasms, Experimental / pathology,  radiotherapy*
Radioisotopes / metabolism,  therapeutic use*
Tissue Distribution
Reg. No./Substance:
0/DNA, Neoplasm; 0/Radioisotopes; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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