| Differences in the composition of intestinal Bifidobacterium species and the development of allergic diseases in infants in rural Japan. | |
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MedLine Citation:
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PMID: 17430346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Bifidobacterium is a dominant genus in the intestinal microbiota of infants and comprises many different species. A series of studies performed in northern Europe showed differences in the composition of Bifidobacterium species between allergic infants and healthy controls. Additional studies are needed to confirm this observation. OBJECTIVE: To investigate the composition of fecal Bifidobacterium species in allergic infants and healthy controls in Japan, using molecular methods. METHODS: Full-term born babies were followed up to 6 months of age at a local hospital in rural Japan. The presence or absence of allergy was determined based on allergic symptoms and skin prick tests. Fecal Bifidobacterium species in allergic infants (n=10), and healthy controls (n=16) were evaluated using nine Bifidobacterium species-specific or group-specific primers based on 16S rDNA sequences at 1, 3, and 6 months of age. RESULTS: The number of the infants in whom no Bifidobacterium species could be found was four (15.4%) at 1 month, two (7.7%) at 3 months, and one (3.3%) at 6 months of age, all of whom were healthy controls. At 1 month of age, allergic infants had a higher prevalence f the Bifidobacterium catenulatum group than healthy controls (60.0% vs. 6.3%, P<0.01). At 6 months of age, allergic infants had a higher prevalence of B. bifidum than healthy controls (70.0% vs. 12.5%, P<0.01). These differences were not related to feeding method. CONCLUSIONS: Our results in infants in rural Japan support the hypothesis that a compositional difference in intestinal Bifidobacterium species may be associated with the development of allergy in early infancy, although the responsible species might vary among countries or races. |
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Authors:
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S Suzuki; N Shimojo; Y Tajiri; M Kumemura; Y Kohno |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 37 ISSN: 0954-7894 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-13 Completed Date: 2007-09-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
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Languages: eng Pagination: 506-11 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Graduate School of Medicine Chiba University, Inohana, Chuo-ku, Chiba, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bifidobacterium
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classification*,
genetics,
isolation & purification Feces / microbiology Female Follow-Up Studies Humans Hypersensitivity / immunology* Infant Infant Nutritional Physiological Phenomena Intestines / microbiology* Japan Male Polymerase Chain Reaction / methods RNA, Bacterial / genetics RNA, Ribosomal, 16S / genetics Rural Health / statistics & numerical data Skin Tests |
| Chemical | |
Reg. No./Substance:
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0/RNA, Bacterial; 0/RNA, Ribosomal, 16S |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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