Document Detail


Differences in clinical and immunologic reactivity of patients allergic to grass pollens and to multiple-pollen species. II. Efficacy of a double-blind, placebo-controlled, specific immunotherapy with standardized extracts.
MedLine Citation:
PMID:  2071784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The IgE response of patients only allergic to grass pollens differs from response of patients allergic to multiple-pollen species. The IgE immunoblots to orchard-grass pollens confirmed that polysensitized patients had more proteins revealed than patients only allergic to grass pollens. To determine if both groups of patients present a different response toward specific immunotherapy (IT), a double-blind, placebo-controlled study was performed in 70 patients. Patients receiving the active treatment had a rush IT with either a standardized orchard grass-pollen extract or with a standardized mixed-pollen extract prepared, depending on the sensitivity of the patients. The maintenance dose was defined as that dose effective in grass-pollen IT in previous experiments. The same equipotent maintenance dose was administered for all pollen species. Symptom-medication scores during the pollen season and nasal challenge with orchard grass-pollen grains demonstrated that grass pollen-allergic patients had a significantly improved efficacy by comparison to placebo treatment, whereas polysensitized patients had a nonsignificant improvement. Serum grass-pollen IgG was significantly increased after IT in both treated groups. This study demonstrate that the response toward specific IT differs in patients only allergic to grass pollens by comparison to polysensitized patients.
Authors:
J Bousquet; W M Becker; A Hejjaoui; I Chanal; B Lebel; H Dhivert; F B Michel
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  88     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-20     Completed Date:  1991-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-53     Citation Subset:  AIM; IM    
Affiliation:
Clinique des Maladies Respiratoires, Centre Hospitalier, Universitaire, Montpellier, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Allergens / administration & dosage
Double-Blind Method
Female
Humans
Immunoblotting
Immunoglobulin E / analysis
Immunotherapy / methods*
Male
Nasal Provocation Tests
Placebos
Pollen / immunology*
Rhinitis, Allergic, Seasonal / immunology*,  therapy
Skin Tests
Chemical
Reg. No./Substance:
0/Allergens; 0/Placebos; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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