Document Detail


Differences in the change in the time course of plasma endothelin-1 and endothelin-3 levels after exercise in humans. The response to exercise of endothelin-3 is more rapid than that of endothelin-1.
MedLine Citation:
PMID:  9244368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several studies have indicated that endothelin-1 (ET-1) and endothelin-3 (ET-3) are produced by different cells. Although ET-1 is produced by vascular endothelial cells, these cells do not produce ET-3. The presence of ET-3 in the brain of several species suggests that ET-3 is a novel neuropeptide. It is unclear whether there are differences in the release of ET-1 and ET-3 under various physiological conditions in humans. In the present study, we measured the plasma concentrations of both ET-1 and ET-3 before and after endurance exercise on a cycle ergometer. Male athletes exercised on a cycle ergometer for 30 min at intensity of 130% of their individual ventilatory threshold (VT), which is intense exercise. Plasma ET-1 and ET-3 were greatly elevated by exercise, but there was a marked difference in the time-course of the change in plasma concentration between the two peptides. The level of ET-1 peaked 30 min after exercise, whereas that of ET-3 peaked immediately after exercise. Thus, plasma ET-3 increased faster than plasma ET-1 after exercise. The exercise-induced change in the time course in plasma ET-3, but not in ET-1, is similar to that in plasma norepinephrine which is a neurotransmitter, suggesting that the rapid elevation in plasma ET-3 is partly attributable to the neuronal response to exercise. The observed difference in the change in the time course of plasma ET-1 and ET-3 levels suggests that the mechanisms by which exercise alters the release and/or synthesis of these two peptides differ.
Authors:
S Maeda; T Miyauchi; K Goto; M Matsuda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  61     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1997  
Date Detail:
Created Date:  1997-08-12     Completed Date:  1997-08-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  419-25     Citation Subset:  IM    
Affiliation:
Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Endothelin-1 / blood*
Endothelin-3 / blood*
Exercise / physiology*
Exercise Test
Heart Rate
Humans
Kinetics
Male
Norepinephrine / blood
Physical Endurance
Physical Exertion / physiology
Chemical
Reg. No./Substance:
0/Endothelin-1; 0/Endothelin-3; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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