| Differences in the change in the time course of plasma endothelin-1 and endothelin-3 levels after exercise in humans. The response to exercise of endothelin-3 is more rapid than that of endothelin-1. | |
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MedLine Citation:
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PMID: 9244368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies have indicated that endothelin-1 (ET-1) and endothelin-3 (ET-3) are produced by different cells. Although ET-1 is produced by vascular endothelial cells, these cells do not produce ET-3. The presence of ET-3 in the brain of several species suggests that ET-3 is a novel neuropeptide. It is unclear whether there are differences in the release of ET-1 and ET-3 under various physiological conditions in humans. In the present study, we measured the plasma concentrations of both ET-1 and ET-3 before and after endurance exercise on a cycle ergometer. Male athletes exercised on a cycle ergometer for 30 min at intensity of 130% of their individual ventilatory threshold (VT), which is intense exercise. Plasma ET-1 and ET-3 were greatly elevated by exercise, but there was a marked difference in the time-course of the change in plasma concentration between the two peptides. The level of ET-1 peaked 30 min after exercise, whereas that of ET-3 peaked immediately after exercise. Thus, plasma ET-3 increased faster than plasma ET-1 after exercise. The exercise-induced change in the time course in plasma ET-3, but not in ET-1, is similar to that in plasma norepinephrine which is a neurotransmitter, suggesting that the rapid elevation in plasma ET-3 is partly attributable to the neuronal response to exercise. The observed difference in the change in the time course of plasma ET-1 and ET-3 levels suggests that the mechanisms by which exercise alters the release and/or synthesis of these two peptides differ. |
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Authors:
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S Maeda; T Miyauchi; K Goto; M Matsuda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 61 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-08-12 Completed Date: 1997-08-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 419-25 Citation Subset: IM |
Affiliation:
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Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Endothelin-1 / blood* Endothelin-3 / blood* Exercise / physiology* Exercise Test Heart Rate Humans Kinetics Male Norepinephrine / blood Physical Endurance Physical Exertion / physiology |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/Endothelin-3; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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