Document Detail


Differences in cardio-ventilatory responses to hypobaric and normobaric hypoxia: a review.
MedLine Citation:
PMID:  22779311     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The presence of differences in physiological response to a lowered inspired Po2 mediated by hypobaric hypoxia (HH) or normobaric hypoxia (NH) is controversial. This review examines the brief, acute, and subacute respiratory, cardiovascular, and subjective symptom response to intermediate and severe hypoxic exposure in NH and HH. Brief exposures lead to similar physiological responses; this is not the case in acute/subacute exposures. Extrapolating data from NH studies to HH in longer exposures is inappropriate as physiological responses to hypoxia seem to be influenced by the prevailing ambient pressure, especially in chronic exposures where acute mountain sickness severity is greater in HH than NH. Explanations for the discrepancy between the two modalities include differences in ventilatory patterns, alveolar gas disequilibrium, and dissimilar acute hypoxic ventilatory responses. Awareness and consideration of these key differences between NH and HH is essential to their proper application to kinesiology, altitude, and aviation medicine.
Authors:
Normand A Richard; Michael S Koehle
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  83     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-11     Completed Date:  2012-08-14     Revised Date:  2012-08-24    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  677-84     Citation Subset:  IM; S    
Affiliation:
School of Kinesiology, University of British Columbia, Vancouver, BC, Canada.
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MeSH Terms
Descriptor/Qualifier:
Altitude Sickness / physiopathology*
Anoxia / physiopathology*
Atmospheric Pressure
Carbon Dioxide / metabolism
Cardiovascular System / physiopathology*
Humans
Mountaineering*
Respiratory System / physiopathology*
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide
Comments/Corrections
Erratum In:
Aviat Space Environ Med. 2012 Aug;83(8):817

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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