Document Detail


Differences in brain activation between tremor- and nontremor-dominant Parkinson disease.
MedLine Citation:
PMID:  23318516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE To compare differences in functional brain activity between tremor- and nontremor-dominant subtypes of Parkinson disease (PD) using functional magnetic resonance imaging. DESIGN In our study, patients with tremor-dominant PD and those with nontremor-dominant PD performed a grip task, and the results obtained were compared using voxelwise analysis. Areas of the brain that were significantly different were then examined using a region-of-interest analysis to compare these patients with healthy controls. Voxel-based morphometry was used to determine macroscopic differences in gray and white matter volume between patient groups. SETTING University-affiliated research institution. PARTICIPANTS A total of 20 drug-naive patients with PD (10 with tremor-dominant PD and 10 with nontremor-dominant PD) and a total of 20 healthy controls. MAIN OUTCOME MEASURES Blood oxygenation level-dependent activation and percent signal change. RESULTS Robust findings across both voxelwise and region-of-interest analyses showed that, compared with patients with tremor-dominant PD, patients with nontremor-dominant PD had reduced activation in the ipsilateral dorsolateral prefrontal cortex, the globus pallidus interna, and the globus pallidus externa. Region-of-interest analyses confirmed that patients with nontremor-dominant PD had reduced activity in the ipsilateral dorsolateral prefrontal cortex, the globus pallidus interna, and the globus pallidus externa compared with patients with tremor-dominant PD and healthy controls. Patients with tremor-dominant PD had increased activity in the contralateral dorsolateral prefrontal cortex compared with patients with nontremor-dominant PD and healthy controls. These results could not be explained by differences in gray or white matter volume. CONCLUSIONS Reduced brain activity occurs in the prefrontal cortex and globus pallidus of patients with nontremor-dominant PD compared with both patients with tremor-dominant PD and healthy controls, which suggests that functional magnetic resonance imaging is a promising technique to understand differences in brain activation between subtypes of PD.
Authors:
Janey Prodoehl; Peggy J Planetta; Ajay S Kurani; Cynthia L Comella; Daniel M Corcos; David E Vaillancourt
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JAMA neurology     Volume:  70     ISSN:  2168-6157     ISO Abbreviation:  JAMA Neurol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-15     Completed Date:  2013-03-26     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101589536     Medline TA:  JAMA Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  100-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Kinesiology, University of Illinois, Chicago, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain / physiopathology*
Female
Functional Laterality / physiology
Globus Pallidus / physiopathology
Hand Strength / physiology
Humans
Magnetic Resonance Imaging / instrumentation,  methods*
Male
Middle Aged
Neuropsychological Tests
Parkinson Disease / classification,  physiopathology*
Prefrontal Cortex / physiopathology
Tremor / classification,  physiopathology*
Grant Support
ID/Acronym/Agency:
R01 NS052318/NS/NINDS NIH HHS; R01 NS075012/NS/NINDS NIH HHS; R01-NS-28127/NS/NINDS NIH HHS; R01-NS-40902/NS/NINDS NIH HHS; R01-NS-52318/NS/NINDS NIH HHS; R01-NS-58487/NS/NINDS NIH HHS
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