| Differences in blood pressure and vascular responses associated with ambient fine particulate matter exposures measured at the personal versus community level. | |
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MedLine Citation:
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PMID: 20935292 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background Higher ambient fine particulate matter (PM(2.5)) levels can be associated with increased blood pressure and vascular dysfunction. Objectives To determine the differential effects on blood pressure and vascular function of daily changes in community ambient- versus personal-level PM(2.5) measurements. Methods Cardiovascular outcomes included vascular tone and function and blood pressure measured in 65 non-smoking subjects. PM(2.5) exposure metrics included 24 h integrated personal- (by vest monitors) and community-based ambient levels measured for up to 5 consecutive days (357 observations). Associations between community- and personal-level PM(2.5) exposures with alterations in cardiovascular outcomes were assessed by linear mixed models. Results Mean daily personal and community measures of PM(2.5) were 21.9±24.8 and 15.4±7.5 μg/m(3), respectively. Community PM(2.5) levels were not associated with cardiovascular outcomes. However, a 10 μg/m(3) increase in total personal-level PM(2.5) exposure (TPE) was associated with systolic blood pressure elevation (+1.41 mm Hg; lag day 1, p<0.001) and trends towards vasoconstriction in subsets of individuals (0.08 mm; lag day 2 among subjects with low secondhand smoke exposure, p=0.07). TPE and secondhand smoke were associated with elevated systolic blood pressure on lag day 1. Flow-mediated dilatation was not associated with any exposure. Conclusions Exposure to higher personal-level PM(2.5) during routine daily activity measured with low-bias and minimally-confounded personal monitors was associated with modest increases in systolic blood pressure and trends towards arterial vasoconstriction. Comparable elevations in community PM(2.5) levels were not related to these outcomes, suggesting that specific components within personal and background ambient PM(2.5) may elicit differing cardiovascular responses. |
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Authors:
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Robert D Brook; Robert L Bard; Richard T Burnett; Hwashin H Shin; Alan Vette; Carry Croghan; Michael Phillips; Charles Rodes; Jonathan Thornburg; Ron Williams |
Publication Detail:
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Type: Journal Article Date: 2010-10-08 |
Journal Detail:
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Title: Occupational and environmental medicine Volume: 68 ISSN: 1470-7926 ISO Abbreviation: Occup Environ Med Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422759 Medline TA: Occup Environ Med Country: England |
Other Details:
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Languages: eng Pagination: 224-30 Citation Subset: IM |
Affiliation:
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24 Frank Lloyd Wright Dr, PO Box 322, Ann Arbor, MI 48106, USA; robdbrok@umich.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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